CSF2RB
粒細(xì)胞-巨噬細(xì)胞集落刺激因子低親和力受體β（Colony Stimulating Factor 2 Receptor，Beta，Low-Affinity，CSF2RB），又叫CD131，是一種多重集落刺激因子受體。CSF2RB對JAK/STAT（JAK2，STAT5）和MAP激酶途徑的激活都至關(guān)重要。人IL-3、GM-CSF、IL-5通過細(xì)胞膜表面相應(yīng)的受體發(fā)揮相應(yīng)的生物學(xué)功能。這三種細(xì)胞因子受體由各自特異性的a亞基（IL-3Ra、GM-CSFRa、IL-5Ra）和共有的β亞基組成，三種a亞基競爭性結(jié)合β亞基，形成高親和力受體。a亞基特異性結(jié)合相應(yīng)的細(xì)胞因子，共同亞基（hβc），即CD131，起傳導(dǎo)信號作用。通常將這三種細(xì)胞因子的受體稱IL-3受體系統(tǒng)，在維持造血細(xì)胞增殖、分化、自我更新的平衡中具有重要作用。有研究人員利用轉(zhuǎn)基因小鼠發(fā)現(xiàn)CSF2RB基因的突變在骨髓增生性疾病中起作用，且轉(zhuǎn)基因的小鼠出現(xiàn)了散發(fā)性的神經(jīng)系統(tǒng)疾病。因此，CSF2RB的激活可能與中樞神經(jīng)系統(tǒng)疾病有關(guān)。另有研究揭示CSF2RB相關(guān)信號通路的活化與脊髓損傷有關(guān)。
Recombinant Human CSF2RB 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CSF2RB at 2 μg/ml can bind anti-CSF2RB antibody（CSB-RA006047A0HU）, the EC50 is 0.1594-0.3046 ng/mL.
CSF2RB Antibodies
CSF2RB for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA003029 | CSF2RB Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007339 | Phospho-CSF2RB (Y593) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA200894 | CSF2RB Antibody | Human | ELISA,IHC |
| CSB-PA598159 | CSF2RB Antibody | Human | ELISA,IHC |
| CSB-PA006047LA01HU | CSF2RB Antibody | Human | ELISA, IHC, IF |
| CSB-RA006047A0HU | CSF2RB Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-RA006047MA1HU | CSF2RB Recombinant Monoclonal Antibody | Human | ELISA, IF |
CSF2RB Proteins
CSF2RB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006047MO CSB-EP006047MO CSB-BP006047MO CSB-MP006047MO CSB-EP006047MO-B |
Recombinant Mouse Cytokine receptor common subunit beta (Csf2rb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2RB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006047HU CSB-EP006047HU CSB-BP006047HU CSB-EP006047HU-B |
Recombinant Human Cytokine receptor common subunit beta (CSF2RB), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP006047HU | Recombinant Human Cytokine receptor common subunit beta (CSF2RB), partial (Active) | Mammalian cell |
