CLEC4E
CLEC4E，全稱為C-type lectin domain family 4 member E，是一種鈣依賴性凝集素，在先天免疫系統(tǒng)中充當(dāng)模式識別受體。它負(fù)責(zé)檢測并結(jié)合細(xì)菌和真菌中發(fā)現(xiàn)的異常自身的損傷相關(guān)分子模式(DAMP)和病原體相關(guān)分子模式(PAMP)。CLEC4E蛋白常見別名包括Mincle，它在免疫應(yīng)答中發(fā)揮著重要作用，能夠識別病原體表面的糖類結(jié)構(gòu)，從而啟動免疫反應(yīng)。CLEC4E蛋白與多種疾病相關(guān)，如肺病、狼瘡性腎炎和肥胖等。目前，針對CLEC4E蛋白的藥物研發(fā)正在積極進行中，旨在開發(fā)出能夠調(diào)節(jié)免疫反應(yīng)的新型治療藥物。研究表明，CLEC4E蛋白的表達(dá)水平與疾病的發(fā)生發(fā)展密切相關(guān)，因此，它成為了一個重要的藥物靶點。
熱銷產(chǎn)品
CLEC4E Antibody (CSB-PA891553LA01HU)
驗證數(shù)據(jù)
IHC image of CSB-PA891553LA01HU diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA891553LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of U251 cells with CSB-PA891553LA01HU at 1:250, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
CLEC4E Antibodies
CLEC4E for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA891553LA01HU | CLEC4E Antibody | Human | ELISA, IHC, IF |
CLEC4E Proteins
CLEC4E Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP891553HU CSB-EP891553HU CSB-BP891553HU CSB-MP891553HU CSB-EP891553HU-B |
Recombinant Human C-type lectin domain family 4 member E (CLEC4E), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
