CLDN18
CLDN18，即緊密連接蛋白18，別名Claudin-18。CLDN18由人類CLDN18基因編碼，該基因位于3號染色體的3q28區域。CLDN18是一種緊密連接蛋白，主要參與形成細胞間的緊密連接，調節細胞旁路的通透性和維持上皮細胞層的完整性。其作用機制涉及與細胞膜上的其他緊密連接蛋白相互作用，形成穩定的緊密連接結構，控制分子和離子在細胞間的流動。CLDN18在肺泡上皮細胞和胃上皮細胞中高度表達，對于肺和胃的發育和功能至關重要。CLDN18的異常表達與多種疾病相關，包括肺癌和胃癌。特別是在肺癌中，CLDN18的表達與腫瘤的侵襲性和預后不良相關，是潛在的診斷標志物和治療靶點。
熱銷產品
Recombinant Macaca fascicularis Claudin 18.2 (CLDN18.2)-VLPs (Active) (CSB-MP4304MOV)
驗證數據
CSB-MP4304MOV is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CLDN18 at 5 μg/ml can bind Anti-CLDN18.2 recombinant Antibody (CSB-RA005498A1HU), the EC50 is 2.806-3.641 ng/ml.
The purity of VLPs was greater than 90% as determined by SEC-HPLC
Recombinant Mouse Claudin-18.2 (Cldn18.2)-VLPs (Active) (CSB-MP005498MO(F3))
驗證數據
-WB.jpg)
CSB-MP005498MO(F3) is detected by Mouse anti-6*His monoclonal antibody.
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Cldn18 at 5 μg/ml can bind Anti-CLDN18.2 recombinant antibody (CSB-RA005498A1HU), the EC50 is 6.115-11.01 ng/mL.
Recombinant Human Claudin-18.2 (CLDN18.2)-VLPs (Active) (CSB-MP005498HU(A5))
驗證數據
-WB.jpg)
Western Blot
CSB-MP005498HU(A5) is detected by Mouse anti-6*His monoclonal antibody.The three bands respectively correspond to monomer, Homodimer, Homotrimer
-AC1.jpg)
Activity
Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.
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The presence of VLP-like structures was confirmed by TEM
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Western Blot
CSB-MP005498HU(A5) is detected by Anti-Claudin 18 Antibody.The two bands respectively correspond to monomer, Homodimer
CLDN18 Recombinant Monoclonal Antibody (CSB-RA005498A2HU)
驗證數據
Untransfected KATO3 cells surface (green line), transfected Human CLDN18.2 KATO3 stable cells surface (red line) and transfected Human CLDN18.1 NIH-3T3 stable cells surface (blue line) were stained with anti-CLDN18.2 antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The Binding Activity of Human CLDN18.2 with Anti-CLDN18 recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN18.2 (CSB-MP005498HU(A5)) at 5 μg/mL can bind Anti-CLDN18 recombinant antibody, the EC50 is 2.947-8.782 ng/mL.
CLDN18 Antibodies
CLDN18 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005498GA01HU | CLDN18 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA005498ESR1HU | CLDN18 Antibody | Human | ELISA, WB, IHC |
| CSB-PA005498ESR2HU | CLDN18 Antibody | Human, Rat | ELISA, WB, IHC |
| CSB-MA148581 | CLDN18 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-PA005498LA01HU | CLDN18 Antibody | Human | ELISA, IHC, IF |
| CSB-PA005498LC01HU | CLDN18 Antibody, FITC conjugated | Human | |
| CSB-PA005498LB01HU | CLDN18 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA005498A2HU | CLDN18 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CLDN18 Proteins
CLDN18 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005498MO1 CSB-EP005498MO1 CSB-BP005498MO1 CSB-MP005498MO1 CSB-EP005498MO1-B |
Recombinant Mouse Claudin-18 (Cldn18), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005498MO | Recombinant Mouse Claudin-18 (Cldn18) | in vitro E.coli expression system |
CLDN18 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005498HU1 CSB-EP005498HU1 CSB-BP005498HU1 CSB-MP005498HU1 CSB-EP005498HU1-B |
Recombinant Human Claudin-18 (CLDN18), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005498HU | Recombinant Human Claudin-18 (CLDN18) | in vitro E.coli expression system |
| CSB-MP005498HU(A5) | Recombinant Human Claudin-18.2 (CLDN18.2)-VLPs (Active) | Mammalian cell |
| CSB-EP005498HU2 | Recombinant Human Claudin-18 (CLDN18), partial | E.coli |
| CSB-EP005498HU2b0 | Recombinant Human Claudin-18 (CLDN18), partial | E.coli |
| CSB-MP005498HU(A5)l5 | Recombinant Human Claudin-18.2 (CLDN18.2)-VLPs, Fluorescent (Active) | Mammalian cell |
| CSB-MP005498HU(A5)-D | Recombinant?Human?Claudin-18.2?(CLDN18.2)-Detergent (Active) | Mammalian cell |
CLDN18 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP610823BO1 CSB-EP610823BO1 CSB-BP610823BO1 CSB-MP610823BO1 CSB-EP610823BO1-B |
Recombinant Bovine Claudin-18 (CLDN18), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF610823BO | Recombinant Bovine Claudin-18 (CLDN18) | in vitro E.coli expression system |
