CCR4
CCR4：Treg細(xì)胞上的關(guān)鍵趨化因子受體，有望成為新型腫瘤免疫治療靶點(diǎn)!
C-C趨化因子受體（C-C chemokine receptor type 4，CCR4），也稱為CD194，由包含7次跨膜結(jié)構(gòu)域的多肽鏈組成，屬于G蛋白偶聯(lián)受體家族。其含360個(gè)氨基酸，分子量約為41kD，主要表達(dá)于各種淋巴細(xì)胞和組織，其配體包括多種趨化因子。作為重要的趨化因子受體，CCR4與其它趨化因子配體產(chǎn)生結(jié)合，行使其功能，參與調(diào)控人類自身免疫疾病過(guò)程，主要包括特應(yīng)性皮炎、哮喘、皮膚T細(xì)胞淋巴瘤。過(guò)去，研究人員對(duì)趨化因子的認(rèn)識(shí)限于在炎癥反應(yīng)中的趨化作用，然而越來(lái)越多的研究顯示，趨化因子結(jié)合其受體在腫瘤細(xì)胞的浸潤(rùn)性生長(zhǎng)，遠(yuǎn)處轉(zhuǎn)移等行為中發(fā)揮重要作用。CCR4作為腫瘤轉(zhuǎn)移中關(guān)鍵的趨化因子受體，多項(xiàng)研究已證實(shí)，CCR4高表達(dá)與血液系統(tǒng)腫瘤以及惡性實(shí)體瘤的浸潤(rùn)和預(yù)后密切相關(guān)，靶向CCR4有望成為惡性腫瘤免疫治療的新策略。
CUSABIO-哺乳包膜VLPs平臺(tái)成功開(kāi)發(fā)CCR4全長(zhǎng)膜蛋白（7次跨膜），展示了完整生物活性。
熱銷產(chǎn)品
Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active) (CSB-MP004843HU)
驗(yàn)證數(shù)據(jù)
CSB-MP004843HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 10 μg/ml can bind Anti-CCR4 recombinant antibody(CSB-RA004843MA01HU), the EC50 is 362.3-630.8 ng/mL.
The presence of VLP-like structures was confirmed by TEM
Recombinant Human C-C chemokine receptor type 4 (CCR4) (Active) (CSB-CF004843HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR4 at 5 μg/ml can bind Anti-CCR4 recombinant antibody (CSB-RA004843MA01HU). The EC50 is 2.803-3.369 ng/mL.
Activity
Human CCR4 Full Length Protein captured on CM5 chip can bind Human CCR4 Monoclonal Antibody (CSB-RA004843MA01HU) with an affinity constant of 3.16 nM as detected by SPR Assay(Biacore T200).
Activity
Human CCR4 Monoclonal Antibody (CSB-RA004843MA01HU) captured on Protein A Chip can bind Human CCR4 Full Length Protein with an affinity constant of 1.71 nM as detected by MetaSPR Assay (in presence of FOS-12)(WeSPRTM 200) .
CCR4 Antibodies
CCR4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005336 | CCR4 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA006992 | CCR4 Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA004843LA01HU | CCR4 Antibody | Human | ELISA, IHC, IF |
| CSB-RA004843MA01HU | CCR4 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CCR4 Proteins
CCR4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004843HU1 CSB-BP004843HU1 CSB-MP004843HU1 CSB-EP004843HU1-B |
Recombinant Human C-C chemokine receptor type 4 (CCR4), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004843HU | Recombinant Human C-C chemokine receptor type 4 (CCR4) (Active) | in vitro E.coli expression system |
| CSB-EP004843HU1 | Recombinant Human C-C chemokine receptor type 4 (CCR4), partial | E.coli |
| CSB-MP004843HU | Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active) | Mammalian cell |
CCR4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP004843MO1 CSB-EP004843MO1 CSB-BP004843MO1 CSB-MP004843MO1 CSB-EP004843MO1-B |
Recombinant Mouse C-C chemokine receptor type 4 (Ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004843MO | Recombinant Mouse C-C chemokine receptor type 4 (Ccr4) | in vitro E.coli expression system |
CCR4 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP373023AVC CSB-EP373023AVC CSB-BP373023AVC CSB-MP373023AVC CSB-EP373023AVC-B |
Recombinant Aspergillus clavatus Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP373090NEZ CSB-EP373090NEZ CSB-BP373090NEZ CSB-MP373090NEZ CSB-EP373090NEZ-B |
Recombinant Neosartorya fischeri Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Aspergillus niger (strain CBS 513.88 / FGSC A1513)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP382681AVE CSB-EP382681AVE CSB-BP382681AVE CSB-MP382681AVE CSB-EP382681AVE-B |
Recombinant Aspergillus niger Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP488323EMA CSB-EP488323EMA CSB-BP488323EMA CSB-MP488323EMA CSB-EP488323EMA-B |
Recombinant Enterocytozoon bieneusi Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Nosema ceranae (strain BRL01) (Microsporidian parasite)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP505300NHO CSB-EP505300NHO CSB-BP505300NHO CSB-MP505300NHO CSB-EP505300NHO-B |
Recombinant Nosema ceranae Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP527967SXV CSB-EP527967SXV CSB-BP527967SXV CSB-MP527967SXV CSB-EP527967SXV-B |
Recombinant Schizosaccharomyces pombe Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Aspergillus terreus (strain NIH 2624 / FGSC A1156)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP607711APT CSB-EP607711APT CSB-BP607711APT CSB-MP607711APT CSB-EP607711APT-B |
Recombinant Aspergillus terreus Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP609913EUG CSB-EP609913EUG CSB-BP609913EUG CSB-MP609913EUG CSB-EP609913EUG-B |
Recombinant Phaeosphaeria nodorum Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Coccidioides immitis (strain RS) (Valley fever fungus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP625614DUV CSB-EP625614DUV CSB-BP625614DUV CSB-MP625614DUV CSB-EP625614DUV-B |
Recombinant Coccidioides immitis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP652755DPA CSB-EP652755DPA CSB-BP652755DPA CSB-MP652755DPA CSB-EP652755DPA-B |
Recombinant Aspergillus oryzae Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP681250NGS CSB-EP681250NGS CSB-BP681250NGS CSB-MP681250NGS CSB-EP681250NGS-B |
Recombinant Neosartorya fumigata Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP685477CZD CSB-EP685477CZD CSB-BP685477CZD CSB-MP685477CZD CSB-EP685477CZD-B |
Recombinant Candida albicans Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP685553EKF CSB-EP685553EKF CSB-BP685553EKF CSB-MP685553EKF CSB-EP685553EKF-B |
Recombinant Emericella nidulans Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Ustilago maydis (strain 521 / FGSC 9021) (Smut fungus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP700033UBS CSB-EP700033UBS CSB-BP700033UBS CSB-MP700033UBS CSB-EP700033UBS-B |
Recombinant Ustilago maydis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP731895DIS CSB-EP731895DIS CSB-BP731895DIS CSB-MP731895DIS CSB-EP731895DIS-B |
Recombinant Debaryomyces hansenii Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP731995YAP CSB-EP731995YAP CSB-BP731995YAP CSB-MP731995YAP CSB-EP731995YAP-B |
Recombinant Yarrowia lipolytica Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP732018KBK CSB-EP732018KBK CSB-BP732018KBK CSB-MP732018KBK CSB-EP732018KBK-B |
Recombinant Kluyveromyces lactis Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP739340CZI CSB-EP739340CZI CSB-BP739340CZI CSB-MP739340CZI CSB-EP739340CZI-B |
Recombinant Candida glabrata Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP751781DOT CSB-EP751781DOT CSB-BP751781DOT CSB-MP751781DOT CSB-EP751781DOT-B |
Recombinant Ashbya gossypii Glucose-repressible alcohol dehydrogenase transcriptional effector (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP823404EKH CSB-EP823404EKH CSB-BP823404EKH CSB-MP823404EKH CSB-EP823404EKH-B |
Recombinant Encephalitozoon cuniculi Probable glucose-repressible alcohol dehydrogenase transcriptional effector homolog (CCR4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP839750DO1 CSB-EP839750DO1 CSB-BP839750DO1 CSB-MP839750DO1 CSB-EP839750DO1-B |
Recombinant Dog C-C chemokine receptor type 4 (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF839750DO | Recombinant Dog C-C chemokine receptor type 4 (CCR4) | in vitro E.coli expression system |
CCR4 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP866940DOA CSB-EP866940DOA CSB-BP866940DOA CSB-MP866940DOA CSB-EP866940DOA-B |
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase-like protein CCR4 (CCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR4 Proteins for Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP880175NHA CSB-EP880175NHA CSB-BP880175NHA CSB-MP880175NHA CSB-EP880175NHA-B |
Recombinant Neurospora crassa Glucose-repressible alcohol dehydrogenase transcriptional effector (ccr-4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
