BCL2
BCL2，即B細胞淋巴瘤/白血病-2基因，別名包括Bcl-2家族中的抗凋亡蛋白，如Bcl-2、Bcl-XL、Bcl-W、Mcl-1等。它最初在血液淋巴細胞中被發(fā)現(xiàn)，能夠顯著抑制細胞死亡。BCL2基因的作用機制復(fù)雜，主要通過調(diào)控線粒體途徑來抑制細胞凋亡，它能夠阻止細胞色素c的釋放，抑制活化的Caspases對線粒體的影響，從而維持細胞生存。此外，BCL2還能通過抗氧化作用、抑制鈣離子跨膜流動和調(diào)節(jié)離子通道蛋白功能等多種機制來發(fā)揮作用。BCL2在細胞凋亡的信號通路中扮演著關(guān)鍵角色，它通過與Bax等促凋亡蛋白相互作用，形成二聚體，調(diào)節(jié)線粒體膜的通透性，進而影響細胞色素c的釋放和Caspase級聯(lián)反應(yīng)的激活。BCL2的生物學意義重大，它不僅在細胞存活和凋亡的平衡中發(fā)揮作用，還與多種疾病的發(fā)生發(fā)展密切相關(guān)，包括癌癥、神經(jīng)退行性疾病等。BCL2的功能失調(diào)可能導致細胞凋亡途徑的異常激活，影響細胞的正常生理功能。
熱銷產(chǎn)品
Recombinant Rat Apoptosis regulator Bcl-2 (Bcl2) (CSB-CF002611RA)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BCL2 Recombinant Monoclonal Antibody (CSB-RA564360A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: 293 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, U-937 whole cell lysate, THP-1 whole cell lysate, Raji whole cell lysate, Mouse Spleen whole cell lysate
All lanes: Bcl-2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 27, 23 kDa
Observed band size: 27 kDa
IHC image of CSB-RA564360A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Rat B-cell CLL/lymphoma 2 (BCL2) ELISA kit (CSB-E08854r)
驗證數(shù)據(jù)
貨號：CSB-E08854r
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
BCL2 Antibodies
BCL2 for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002611LC01MO | Bcl2 Antibody, FITC conjugated | Mouse | |
| CSB-PA002611LA01MO | Bcl2 Antibody | Mouse | ELISA, IHC |
| CSB-PA002611LB01MO | Bcl2 Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA006342 | Phospho-BCL2 (S70) Antibody | Mouse,Rat | WB, ELISA |
BCL2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA002611GA01HU | BCL2 Antibody | Human,Mouse,Rat,Guinea pig | ELISA,WB,IHC |
| CSB-PA187601 | BCL2 (Ab-56) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA129411 | BCL2 (Ab-70) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA206782 | Phospho-BCL2 (Thr56) Antibody | Human | ELISA,IHC |
| CSB-PA824266 | Phospho-BCL2 (Ser70) Antibody | Human | ELISA,IHC |
| CSB-PA971921 | Phospho-BCL2 (Ser87) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000484 | Phospho-BCL2 (S70) Antibody | Human,Monkey | WB, IHC, IP, ELISA |
| CSB-PA000485 | Phospho-BCL2 (T56) Antibody | Human | WB, IHC, IP, IF, ELISA |
| CSB-PA000982 | BCL2 Antibody | Human,Monkey | WB, IHC, ELISA |
| CSB-PA000983 | BCL2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA000984 | BCL2 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA040190 | Phospho-BCL2 (T69) Antibody | Human | IHC, IF, ELISA |
| CSB-PA040191 | Phospho-BCL2 (S87) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA040192 | Phospho-BCL2 (T74) Antibody | Human | IHC, ELISA |
| CSB-PA597947 | BCL2 Antibody | Human | ELISA,WB |
| CSB-PA832691 | BCL2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA703826 | BCL2 Antibody | Mouse,Rat | WB,ELISA |
| CSB-PA12959A0Rb | BCL2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA12959B0Rb | BCL2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA12959C0Rb | BCL2 Antibody, FITC conjugated | Human | |
| CSB-PA12959D0Rb | BCL2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA002611A0HU | BCL2 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, IHC, FC |
| CSB-RA564360A0HU | BCL2 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-MA002611A0m | BCL2 Monoclonal Antibody | Human, Mouse | ELISA, WB, FC |
BCL2 for H, M, R
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-MA000196 | BCL2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
BCL2 Proteins
BCL2 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002611CH1 CSB-EP002611CH1 CSB-BP002611CH1 CSB-MP002611CH1 CSB-EP002611CH1-B |
Recombinant Chicken Apoptosis regulator Bcl-2 (BCL2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002611CH | Recombinant Chicken Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
BCL2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002611HU1 CSB-BP002611HU1 CSB-MP002611HU1 CSB-EP002611HU1-B |
Recombinant Human Apoptosis regulator Bcl-2 (BCL2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002611HU | Recombinant Human Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
| CSB-EP002611HU1 | Recombinant Human Apoptosis regulator Bcl-2 (BCL2), partial | E.coli |
BCL2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002611MO CSB-BP002611MO CSB-MP002611MO CSB-EP002611MO-B |
Recombinant Mouse Apoptosis regulator Bcl-2 (Bcl2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002611MO | Recombinant Mouse Apoptosis regulator Bcl-2 (Bcl2), partial | E.coli |
| CSB-CF002611MO(A4) | Recombinant Mouse Apoptosis regulator Bcl-2 (Bcl2) | in vitro E.coli expression system |
BCL2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002611RA1 CSB-EP002611RA1 CSB-BP002611RA1 CSB-MP002611RA1 CSB-EP002611RA1-B |
Recombinant Rat Apoptosis regulator Bcl-2 (Bcl2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BCL2 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP002611BO1 CSB-EP002611BO1 CSB-BP002611BO1 CSB-MP002611BO1 CSB-EP002611BO1-B |
Recombinant Bovine Apoptosis regulator Bcl-2 (BCL2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF002611BO | Recombinant Bovine Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
BCL2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP744176DO1 CSB-EP744176DO1 CSB-BP744176DO1 CSB-MP744176DO1 CSB-EP744176DO1-B |
Recombinant Dog Apoptosis regulator Bcl-2 (BCL2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BCL2 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP872860DXU1 CSB-EP872860DXU1 CSB-BP872860DXU1 CSB-MP872860DXU1 CSB-EP872860DXU1-B |
Recombinant Cricetulus griseus Apoptosis regulator Bcl-2 (BCL2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF872860DXU | Recombinant Cricetulus griseus Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
BCL2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-CF744176DO | Recombinant Dog Apoptosis regulator Bcl-2 (BCL2) | in vitro E.coli expression system |
BCL2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-CF002611RA | Recombinant Rat Apoptosis regulator Bcl-2 (Bcl2) | in vitro E.coli expression system |
BCL2 ELISA Kit
BCL2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08853h | Human B-cell leukemia/lymphoma 2,Bcl-2 ELISA Kit | serum, plasma, tissue homogenates | 0.225 ng/mL |
BCL2 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08855m | Mouse B-cell leukemia/lymphoma 2,Bcl-2 ELISA Kit | serum, plasma | 3.9 pg/mL |
BCL2 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08854r | Rat B-cell CLL/lymphoma 2 (BCL2) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
