ATRX
ATRX，全稱為ATP依賴性染色質(zhì)重塑因子6，是一種參與細(xì)胞核基質(zhì)和染色質(zhì)相互作用的蛋白質(zhì)。它含有ATP酶和螺旋酶結(jié)構(gòu)域，屬于SWI/SNF家族的染色質(zhì)重塑蛋白。ATRX蛋白與多種疾病相關(guān)，包括α地中海貧血/智力障礙綜合征X連鎖型（ATRX綜合征）、神經(jīng)膠質(zhì)瘤、胰腺神經(jīng)內(nèi)分泌腫瘤和骨肉瘤等。研究表明，ATRX蛋白的突變會(huì)導(dǎo)致基因組不穩(wěn)定和端粒維持異常，從而促進(jìn)腫瘤發(fā)生。因此，ATRX蛋白成為癌癥和遺傳病研究的重要靶點(diǎn)。
目前，針對(duì)ATRX蛋白的藥物研發(fā)主要集中在抑制劑的開(kāi)發(fā)上。例如，NU6027最初是作為CDK2抑制劑開(kāi)發(fā)的，但后來(lái)發(fā)現(xiàn)它能夠抑制ATR蛋白，從而提高乳腺癌和卵巢癌細(xì)胞系對(duì)順鉑的敏感性。最新的進(jìn)入臨床試驗(yàn)的ATR抑制劑的臨床研究正在評(píng)估其抗腫瘤活性。此外，亞葉酸鈣和甲氨蝶呤等藥物也被發(fā)現(xiàn)能夠與ATRX蛋白相互作用，從而影響腫瘤細(xì)胞的生長(zhǎng)和存活。
熱銷產(chǎn)品
ATRX Antibody (CSB-PA002437LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002437LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA002437LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA002437LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
ATRX Antibodies
ATRX for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA947796 | ATRX Antibody | Human,Mouse | ELISA,IF |
| CSB-PA030136 | ATRX Antibody | Human,Mouse | IF, ELISA |
| CSB-PA002437LA01HU | ATRX Antibody | Human | ELISA, IHC, IF |
| CSB-PA002437LB01HU | ATRX Antibody, HRP conjugated | Human | ELISA |
| CSB-PA002437LC01HU | ATRX Antibody, FITC conjugated | Human |
ATRX Proteins
ATRX Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP002437HU CSB-EP002437HU CSB-BP002437HU CSB-MP002437HU CSB-EP002437HU-B |
Recombinant Human Transcriptional regulator ATRX (ATRX), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
