ABL1
ABL1，別名c-Abl、p150、BCR-ABL1等。它是一種由ABL1基因編碼的非受體酪氨酸激酶，主要在各種細(xì)胞中表達(dá)，包括造血細(xì)胞。ABL1的作用機(jī)制涉及多種生物學(xué)過(guò)程，包括細(xì)胞信號(hào)傳導(dǎo)、細(xì)胞周期控制、細(xì)胞分化和凋亡。在細(xì)胞中，ABL1通過(guò)磷酸化多種底物蛋白來(lái)調(diào)控信號(hào)轉(zhuǎn)導(dǎo)途徑，影響細(xì)胞的生長(zhǎng)、運(yùn)動(dòng)和存活。ABL1的異常激活與多種癌癥的發(fā)生發(fā)展相關(guān)，尤其是與費(fèi)城染色體陽(yáng)性的慢性髓性白血病(CML)有關(guān)，這是由于ABL1基因與BCR基因的融合導(dǎo)致的。這種融合蛋白具有持續(xù)的酪氨酸激酶活性，導(dǎo)致細(xì)胞失控增殖。ABL1也是多種癌癥治療藥物的靶點(diǎn)，如伊馬替尼（Imatinib），它通過(guò)抑制ABL1的激酶活性來(lái)治療CML和其他ABL1相關(guān)的癌癥。
熱銷產(chǎn)品
Recombinant Human Tyrosine-protein kinase ABL1 (ABL1), partial (CSB-RP043554h)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ABL1 Antibody (CSB-PA04355A0Rb)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA04355A0Rb diluted at 1:1200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunoprecipitating ABL1 in Hela whole cell lysate
Lane 1: Rabbit control IgG (1µg) instead of CSB-PA04355A0Rb in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA04355A0Rb (6µg) + Hela whole cell lysate (500µg)
Lane 3: Hela whole cell lysate (10µg)
Human Tyrosine-protein kinase ABL1(ABL1) ELISA kit (CSB-EL001105HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL001105HU
規(guī)格：96T/48T
靈敏度：6.25 pg/mL
檢測(cè)范圍：25 pg/mL-1600 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ABL1 Antibodies
ABL1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA04355A0Rb | ABL1 Antibody | Human | ELISA, IHC, IP |
| CSB-PA04355D0Rb | ABL1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA980598 | Phospho-ABL1 (Tyr412) Antibody | Human, Mouse, Rat | ELISA, IHC, IF |
| CSB-PA984556 | Phospho-ABL1 (Tyr204) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA573869 | Phospho-ABL1 (Tyr245) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA001140 | ABL1 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA001141 | ABL1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA008490 | Phospho-ABL1 (Y204) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA008492 | Phospho-ABL1 (T735) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA008493 | Phospho-ABL1 (Y245) Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA008496 | ABL1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA008499 | ABL1 Antibody | Human,Mouse,Rat,Monkey | WB, ELISA |
| CSB-PA547318 | ABL1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA959474 | ABL1 Antibody | Human,Mouse,Rat | IHC, ELISA |
ABL1 Proteins
ABL1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001105HU CSB-EP001105HU CSB-BP001105HU CSB-MP001105HU CSB-EP001105HU-B |
Recombinant Human Tyrosine-protein kinase ABL1 (ABL1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-RP043554h | Recombinant Human Tyrosine-protein kinase ABL1 (ABL1), partial | E.coli |
ABL1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001105MO CSB-EP001105MO CSB-BP001105MO CSB-MP001105MO CSB-EP001105MO-B |
Recombinant Mouse Tyrosine-protein kinase ABL1 (Abl1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ABL1 ELISA Kit
ABL1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL001105HU | Human Tyrosine-protein kinase ABL1(ABL1) ELISA kit | serum, plasma, tissue homogenates | 6.25 pg/mL |
