LRRK2
LRRK2（Leucine-rich repeat kinase 2）是一種具有GTPase和激酶活性的多結(jié)構(gòu)域蛋白，屬于富含亮氨酸重復(fù)激酶家族的一員。該基因編碼的蛋白具有ankyrin重復(fù)區(qū)、富含亮氨酸重復(fù)結(jié)構(gòu)域（LRR）、激酶結(jié)構(gòu)域、類dfg基序、RAS結(jié)構(gòu)域、GTPase結(jié)構(gòu)域、類MLK結(jié)構(gòu)域和WD40結(jié)構(gòu)域。具有GTPase和激酶活性，參與多種細胞生理過程，包括自噬、神經(jīng)突增生調(diào)控、突觸形態(tài)發(fā)生、膜運輸以及線粒體功能等。此外，LRRK2與ERK1/2和Wnt信號通路關(guān)系密切，都對細胞核內(nèi)的功能產(chǎn)生影響。LRRK2通過磷酸化tau、肌動蛋白和微管蛋白等來調(diào)節(jié)細胞中的微管動力學(xué)，這些信號通路共同調(diào)控細胞的多種生理功能。
熱銷產(chǎn)品
Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), partial
驗證數(shù)據(jù)
SDS
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LRRK2 Antibodies
LRRK2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA444926 | LRRK2 Antibody | Human | ELISA,IHC |
| CSB-PA902150 | LRRK2 Antibody | Human | ELISA,IHC |
| CSB-PA722493LA01HU | LRRK2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA722493LB01HU | LRRK2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA722493LC01HU | LRRK2 Antibody, FITC conjugated | Human | |
| CSB-PA722493LD01HU | LRRK2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA797150A0HU | LRRK2 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
LRRK2 Proteins
LRRK2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP722493HU CSB-EP722493HU CSB-BP722493HU CSB-MP722493HU CSB-EP722493HU-B |
Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP722493HU1 | Recombinant Human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), partial | E.coli |
