Recombinant Human Uncharacterized protein C11orf73 (C11orf73)
-
中文名稱：人HIKESHI重組蛋白
-
品名簡稱：Recombinant Human C11orf73 protein
-
貨號：CSB-EP706632HU
-
說明書：
-
規(guī)格：￥1344
-
圖片：
-
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-
-
其他：
產(chǎn)品詳情
-
純度：Greater than 90% as determined by SDS-PAGE.
-
基因名：HIKESHI
-
Uniprot No.：
-
別名：C11orf73; Chromosome 11 open reading frame 73; CK073_HUMAN; FLJ43020; Hikeshi; HSPC138; HSPC179; L7RN6; Lethal Chr 7 Rinchik 6; OPI10; Protein Hikeshi; Uncharacterized protein C11orf73
-
種屬：Homo sapiens (Human)
-
蛋白長度：Full Length
-
來源：E.coli
-
分子量：37.6kDa
-
表達區(qū)域：1-197aa
-
氨基酸序列MFGCLVAGRLVQTAAQQVAEDKFVFDLPDYESINHVVVFMLGTIPFPEGMGGSVYFSYPDSNGMPVWQLLGFVTNGKPSAIFKISGLKSGEGSQHPFGAMNIVRTPSVAQIGISVELLDSMAQQTPVGNAAVSSVDSFTQFTQKMLDNFYNFASSFAVSQAQMTPSPSEMFIPANVVLKWYENFQRRLAQNPLFWKT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering. -
蛋白標簽：N-terminal 6xHis-SUMO-tagged
-
產(chǎn)品提供形式：Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液：If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose. -
儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
-
保質(zhì)期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
-
注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
Datasheet & COA：Please contact us to get it.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
-
功能：Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
-
基因功能參考文獻：
- Our results suggest that HIKESHI is a marker of cancer progression and that the combination of HIKESHI inhibition and hyperthermia is a therapeutic tool for refractory gastric cancer PMID: 28731175
- Depletion of Hikeshi renders HeLa cells proteotoxic stress-sensitive through the abrogation of the nuclear function of HSP70s required for HSF1 regulation. PMID: 28980748
- A novel homozygous variant in HIKESHI was identified in a patient with hypomyelinating leukoencephalopathy with periventricular cysts and vermian atrophy. Modified interactions inside Hikeshi's hydrophobic pockets induce mutant protein instability. PMID: 28000699
- Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.P.V54L mutation in Hikeshi is associated with absence of nuclear HSP70 during heat shock stress. PMID: 26545878
- The crystal structure of Hikeshi explains how Hikeshi participates in the regulation of nuclear import through the recognition of FG-Nups and which part of Hikeshi affects its binding to Hsp70. PMID: 25760597
- identify a nuclear import pathway that operates during heat shock stress and is mediated by an evolutionarily conserved protein, Hikeshi (coded by the C11orf73 gene) binds to FG-Nups and translocates through nuclear pores on its own, showing characteristic features of nuclear transport carriers. PMID: 22541429
顯示更多
收起更多
-
相關疾病：Leukodystrophy, hypomyelinating, 13 (HLD13)
-
亞細胞定位：Cytoplasm. Cytoplasm, cytosol. Nucleus.
-
蛋白家族：OPI10 family
-
數(shù)據(jù)庫鏈接：
Most popular with customers
-
Recombinant Human Transthyretin (TTR) (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human G-protein coupled receptor family C group 5 member D (GPRC5D)-VLPs (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active)
Express system: Mammalian cell
Species: Canis lupus familiaris (Dog) (Canis familiaris)
-
Recombinant Human Lymphocyte antigen 6 complex locus protein G6d (LY6G6D) (Active)
Express system: Yeast
Species: Homo sapiens (Human)
-
Recombinant Human Gastric inhibitory polypeptide receptor(GIPR),partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human C-C chemokine receptor type 9 (CCR9)-VLPs (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Kidney-associated antigen 1(KAAG1) (Active)
Express system: Baculovirus
Species: Homo sapiens (Human)
-
Recombinant Macaca fascicularis Interleukin 1 receptor accessory protein(IL1RAP), partial (Active)
Express system: Mammalian cell
Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
