Recombinant Xenopus laevis Ephrin-B1 (efnb1)

in vitro E.coli expression system

中文名稱：

有爪蟾蜍efnb1重組蛋白
貨號：

CSB-CF007465XBE
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

efnb1
Uniprot No.：

O13097
別名：

efnb1; eplg2; lerk2; Ephrin-B1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; XlERK
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

Full Length of Mature Protein
表達區域：

21-329
氨基酸序列

LGKNLEPVTWNSQNPRFISGKGLVLYPEIGDRLDIICPKGDSSQPYEYYKLYMVRRDQLEACSTVIDPNVLVTCNQPGKEYRFTIKFQEFSPNYMGLEFRRNQDYYITSTSNSTLQGLENREGGVCQTRSMKIIMKVGQDPNAVPPEQLTTTRPSKEADNTGKIATFGPWNGPVENPGKSDTNLSDKPTAGGGVDGFFNSKIAVFAAIGAGCVIFILIIIFLVVLLIKIRKRHRKHTQQRAAALSLSTLASPKCSGNAGSEPSDIIIPLRTTENNYCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May have a role in the developing mesenchymal and nervous tissue.
基因功能參考文獻：
1. interactions between Smurfs and ephrinB1 regulates the maintenance of tissue boundaries through the control of ephrinB protein levels PMID: 23475958
2. Results identify the transcriptional co-repressor xTLE1/Groucho as an EphrinB1 interacting protein. PMID: 21429299
3. Ephrin-B1 and Wnt3A signaling contribute to region-specific neuronal plasticity in the developing optic tectum. PMID: 20346764
4. Tyrosine-298 in ephrin B1 is required for binding Grb4. PMID: 14535844
5. EphrinB1 reverse signaling is required to promote cellular movements into the eye field, and can rescue the FGF receptor-induced repression of retinal fate. respectively. PMID: 14723847
6. Gain- and loss-of-function experiments suggest that Xdsh associates with ephrinB1 and mediates ephrinB1 signalling through downstream members of the PCP pathway during eye field formation. PMID: 16362052
7. recruitment of STAT3 to ephrinB1, and its resulting Jak2-dependent activation and transcription of reporter targets, reveals a signaling pathway from ephrinB1 to the nucle PMID: 17954917
8. ephrinB1 associates with the Par polarity complex protein Par-6 and can compete with the small GTPase Cdc42 for association with Par-6. PMID: 18604196
9. Data demonstrate that phosphorylation of tyrosines 324 and 325 of ephrin B1 disrupts the ephrinB1/Dishevelled interaction, thus modulating retinal progenitor movement that is dependent on the planar cell polarity pathway. PMID: 19005214
顯示更多

收起更多
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Ephrin family
組織特異性：

Expressed at low levels in most tissues with highest levels in the kidney, oocytes, ovary and testis.
數據庫鏈接：

KEGG: xla:394292

UniGene: Xl.302