Recombinant Rat Urotensin-2 receptor (Uts2r)

in vitro E.coli expression system

中文名稱：

大鼠Uts2r重組蛋白
貨號：

CSB-CF025773RA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Uts2r
Uniprot No.：

P49684
別名：

Uts2r; Gpr14; Senr; Urotensin-2 receptor; UR-2-R; G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; SENR; Urotensin II receptor; UR-II-R
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-386
氨基酸序列

MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSA MGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGD VGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLL TLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWL SQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNY LTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSG RSLSSSSQQATETLMLSPVPRNGALL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.
基因功能參考文獻：
1. Expression of GPR14 was increased at mRNA and protein levels in brain from cerebral ischemia rats. PMID: 24878476
2. Key transmembrane domain 1 and 2 residues were identified in urotensin-II receptor (UT) that participate in the formation of the UT receptor binding pocket. PMID: 25175740
3. The dynamic changes of urotensin II receptor in pulmonary arterioles might have an important contribution to the development of pulmonary hypertension and pulmonary arteriole remodeling induced by chronic hypoxia-hypercapnia in rats. PMID: 21180151
4. we report a specific nuclear/perinuclear expression of the U-II receptor in the rat heart, which upon activation by U-II or URP results in different modulatory effects on transcription PMID: 22044114
5. presence of functional nuclear UT in various rat and monkey tissues as well as in human cell lines PMID: 22245063
6. Blockade of the urotensin II receptor improved hypoxia-induced cardiac hypertrophy. PMID: 20870804
7. In rat brain, areas of high, medium, and low expression of urotein II receptor include the arcuate, paraventricular, and pedunculopontine tegmental nuclei, respectively PMID: 20422157
8. These results suggest that the U-II and urotensin II receptor play an important role in the diabetic angiopathy especially in the large artery and maybe imply a new way to prevent the injury of artery in diabetes type 2 PMID: 19906507
9. Results indicate that position 6 of urotensin-II normally occupied by phenylalanine would interact with Met(184) and/or Met(185) of the fourth transmembrane domain of the urotensin-II receptor (GPR14). PMID: 12495432
10. cellular localization of GPR14 receptor protein and a positive inotropic effect of urotensin II in normal rat heart. PMID: 15273242
11. the UT receptor (urotensin II receptor) undergoes internalization, and specific serine residues of the receptor's cytoplasmic tail participate in this process PMID: 15458389
12. Urotensin II-related peptide is the endogenous and functional ligand for urotensin II receptor in the rat (REVIEW) PMID: 15476951
13. analysis of urotensin-II binding sites in Sprague-Dawley rat renal medulla PMID: 16290260
14. Taken together, these data demonstrate that rat astrocytes express high- and low-affinity UII binding sites coupled to G proteins, the high-affinity receptor exhibiting the same pharmacological and functional characteristics as UT. PMID: 16942596
15. These results suggest that urotensin II-related peptide is the endogenous and functional ligand for the urotensin II receptor GPR14 in the rat and mouse, and possibly in the human. PMID: 17628210
16. REsults describe the differential expression of urotensin II receptors in cardiovascular tissues from rats and humans and suggest that it may account for the diverse vascular actions reported for urotensin-II. PMID: 17905478
17. Results compare the ability of urotensin II-related peptide (URP) analogs to compete for [125 I]URP binding and to modulate cytosolic calcium concentration in cultured rat astrocytes. PMID: 18082287
18. Urotensin II receptor expression is significantly enhanced in the myocardium of rats with diabetes in both mRNA and protein levels. PMID: 18280445
19. antagonist palosuran might represent a new therapeutic option in liver cirrhosis with portal hypertension PMID: 18318439
20. This study highlights the major contribution of the conserved Asp(2.50) residue to the functionality of the UT receptor. PMID: 18509066
21. UII and UT mRNA expression were greater in the renal medulla than the cortex of SHR AND WKY rats; however, expression levels were up to threefold higher in SHR tissue PMID: 18701623
22. Increased expression of urotensin 2 receptor in kidney with hypertension or renal failure PMID: 18955095
23. In the aorta, expression levels of urotensin II receptor mRNA was significantly elevated in 11-12-week-old SHR compared with age-matched WKY, similarly to those in the kidney. PMID: 19463745
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Preferentially expressed in neural and sensory tissues.
數據庫鏈接：

KEGG: rno:57305

STRING: 10116.ENSRNOP00000051809

UniGene: Rn.44230