Recombinant Rat Histamine H3 receptor (Hrh3)

in vitro E.coli expression system

中文名稱：

大鼠Hrh3重組蛋白
貨號：

CSB-CF886187RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Hrh3
Uniprot No.：

Q9QYN8
別名：

Hrh3; Histamine H3 receptor; H3R; HH3R
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-445
氨基酸序列

MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR RAFTKLLCPQKLKVQPHGSLEQCWK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).
基因功能參考文獻(xiàn)：
1. indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission. PMID: 28964277
2. Results indicate that in rat nucleus accumbens H3Rs do not modulate dopamine uptake or release, but regulate dopamine synthesis by inhibiting cAMP formation and thus PKA activation PMID: 26169221
3. These data support the hypothesis that H3R could also mediate non-neuronal histamine effects, suggesting its involvement in fluid homeostasis PMID: 25745947
4. H3 and H4 receptors in endothelial cells are potentially important for regulation of blood-brain barrier permeability, including trafficking of immunocompetent cells PMID: 23488566
5. This study confirmed the ability of cultured astrocytes from different rat brain regions to express histamine H3 receptors. PMID: 24432407
6. results indicate that co-stimulation of post-synaptic D1 and H3 receptors may indirectly regulate basal dopamine release in the rat striatum and provide in vivo evidence for a functional interaction between D1 and H3 receptors in the basal ganglia PMID: 23896530
7. ZEL-H16 is a novel and potent nonimidazole agonist of H3R, which might serve as a pharmacological tool for future investigations or as possible therapeutic agent of H3R. PMID: 22870296
8. Finsings show that short, but not long, isoforms fulfill the function of autoreceptor and thereby confirm the hypothesis that H3 receptor isoforms have distinct functional roles in the brain PMID: 22356432
9. histamine released from degranulated unstainable mast cells induces a transient increase in presynaptic autoinhibitory HRH3 immunoreactivity and mRNA expression as a mechanism to counteract histamine neurotoxicity PMID: 22277566
10. Data suggest that brain histamine H(3) receptors, and especially those expressed in the prefrontal cortex, play an important role in the autoregulation of histamine neurotransmission. PMID: 22050612
11. the histamine H(3) receptor is involved in the protection against gastric lesions in the rat stomach following administration of concentrated HCl PMID: 21839070
12. the involvement of histamine H(3) receptors in the neurotransmission of perivascular adrenergic and CGRPergic nerves PMID: 21272571
13. D(1)-H(3) receptor heteromers work as processors integrating dopamine- and histamine-related signals involved in controlling the function of striatal neurons of the direct striatal pathway. PMID: 21173143
14. The aim of this work was to investigate the effects of essential splice signals on intron retention in histamine H3 receptors and to identify sequence elements that determine the differences in splicing between rats and mice. PMID: 19446035
15. Inhibition of depolarization-stimulated histamine synthesis by the histamine H(3) receptor agonist imetit was impaired by preincubation with pertussis toxin. PMID: 15465923
16. In rat thalamus, histamine H(1) receptor and isoforms of H(3) receptor were expressed predominantly in the midline and intralaminar areas PMID: 15899242
17. oligomers of native hrh3 in rat forebrain membranes PMID: 15928831
18. H(3) receptor mRNA expression increased in caudate putamen of postischemic brain but decreased in globus pallidus and thalamus. Binding was increased in cortex, caudate-putamen, globus pallidus, and hippocampus. PMID: 16181737
19. Histaminergic neurons protect the developing hippocampus from KA-induced neuronal damage, with regulation of neuronal survival being at least partly mediated through H3 receptors. PMID: 16436594
20. Taken together our results indicate that agonist binding promotes the down-regulation of striatal H3 receptors resulting in a significant loss of function. PMID: 16715497
21. Processing of proprioceptive information at the level of the mesencephalic trigeminal neurons is controlled via histamine H1 and H3 receptors through different postsynaptic mechanisms. PMID: 16797837
22. H3 receptor density in cortical tissue of SHR animals increases with age. PMID: 17531160
23. The purpose of this study was to identify the structural requirements for H3 antagonistic activity via quantitative structure-activity relationship (QSAR) studies and receptor modeling/docking techniques. PMID: 17561422
24. Data describe the influence of (R)-alpha-methylhistamine on the histamine H3 receptor in the rat gastrointestinal tract. PMID: 17806162
25. H3 receptors play an important role in regulation of hippocampal theta oscillation, representing one of the probable mechanisms involved in histamine-induced modulation of higher brain functions, such as attention and learning. PMID: 17940197
26. These data suggest that [18F]fluoroproxyfan can be potentially useful to image histamine H3 receptor noninvasively in the human brain by positron emission tomography. PMID: 17998102
27. Data show that histamine H3 and H4 receptors are expressed on distinct endocrine cell types in the rat fundic mucosa. PMID: 18345490
28. H(3)R is localized mainly around submucosal glands and plays an important role in the secretion of submucosal glands in the nose. PMID: 18564330
29. This is the first evidence that histaminergic neurons are organized into functionally distinct circuits that influence different brain regions, and display selective control mechanisms. PMID: 19490084
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Expressed abundantly in brain, most notably throughout the thalamus, the ventromedial hypothalamus and the caudate nucleus. Isoform 1 is largely predominant in all tissues.
數(shù)據(jù)庫鏈接：

KEGG: rno:85268

UniGene: Rn.7617