Recombinant Rat Alpha-1D adrenergic receptor (Adra1d)

in vitro E.coli expression system

中文名稱：

Recombinant Rat Alpha-1D adrenergic receptor(Adra1d)
貨號：

CSB-CF001387RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Adra1d
Uniprot No.：

P23944
別名：

Adra1d; Adra1a; Alpha-1D adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1D adrenoreceptor; Alpha-1D adrenoceptor; RA42
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區(qū)域：

1-561
氨基酸序列

MTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDN QSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRH LQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILS LCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFC GITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRI HCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFF VLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRR RLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKP ASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGA EAVICQAYEPGDYSNLRETDI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.
基因功能參考文獻：
1. These results suggest that alpha-blockade reduces the urethral resistance associated with detrusor-sphincter dyssynergia, thus improving voiding efficiency in SCI rats. PMID: 27605559
2. NA promotes HSC-T6 cell activation, proliferation and secretion of ECM in vitro via activation of Galpha-coupled alpha1B-AR and alpha1D-AR and the PKC-PI3K-AKT signaling pathway. PMID: 25283507
3. Data suggest Adra1d expression is up-regulated in diabetic kidney; PPAR (peroxisome proliferator-activated receptor) activation (via PPAR alpha or gamma agonists as hypoglycemic agents) suppresses renal expression of Adra1d in diabetic nephropathy. PMID: 24772448
4. The alpha(1D)-adrenergic receptor is involved in methamphetamine-induced hyperthermia and neurotoxicity. PMID: 23283760
5. The effect of Ang II on a1B-AR mRNA seems to be influenced by the absence of a1D-AR in aortic smooth muscle cells. PMID: 21951585
6. activation of alpha(1D)-AR releases ATP, which induces P2X(7) receptors to increase [Ca(2+)](i) but not to stimulate protein secretion in lacrimal glands PMID: 21685341
7. pressor nerve responses in the pithed rat involve both alpha(1A) and alpha(1D)-adrenoceptor PMID: 21376031
8. AT(1)R and alpha1D -adrenoceptor may form heterodimers, and may play a role in preeclampsia. PMID: 20102360
9. physical and psychological stressors resulted in a rapid upregulation of alpha(1d) ADR mRNA in the dentate gyrus PMID: 20138850
10. the expression, cellular localization and coupling to membrane signalling (inositol phosphate accumulation) of alpha(1)-adrenoceptor subtypes in a native tissue PMID: 20511116
11. Inhibition of Adra1d leads to an increase in myoblast death in conditions that are generally associated with myoblast survival. PMID: 20110686
12. cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors PMID: 14736874
13. influence of adrenergic activity on bladder contractility increases with aging is due to overexpression of the AR1D PMID: 18581117
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA1D sub-subfamily
組織特異性：

Vas deferens, hippocampus, cerebral cortex, aorta, brain stem, heart and spleen.
數(shù)據(jù)庫鏈接：

KEGG: rno:29413

STRING: 10116.ENSRNOP00000028877

UniGene: Rn.11314