Recombinant Rat Adenosine monophosphate-protein transferase FICD (Ficd)

in vitro E.coli expression system

中文名稱：

大鼠Ficd重組蛋白
貨號：

CSB-CF718334RA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Ficd
Uniprot No.：

Q6AY47
別名：

Ficd; Protein adenylyltransferase FICD; AMPylator FICD; De-AMPylase FICD; FIC domain-containing protein
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-458
氨基酸序列

MILMPMASVVAVAEPKWVSVWGRFLWMTLLSMALGSLLALLLPLGAVEEQCLAVLRGFHL LRSKLDRAQHVVTKCTSPSTELSVTSRDAGLLTVKTKASPAGKLEAKAALNQALEMKRQG KRGKAHKLFLHALKMDPGFVDALNELGIFSEEDKDIIQADYLYTRALTISPFHEKALINR DRTLPLVEEIDQRYFSVLDSKVRKVMSIPKGSSALRRVMEETYYHHIYHTVAIEGNTLTL AEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINSTLVSRIGSVTIDHMLEIHRRVLGY VDPVEAGRFRRTQVLVGHHIPPHPRDVEKQMQEFTQWLNSEDAMNLHPVEFAALAHYKLV YIHPFIDGNGRTSRLLMNLILMQAGYPPITIRKEQRSEYYHVLEVANEGDVRPFIRFIAK CTEVTLDTLLLATTEYSAALPEAQPNHSGFKETLPVRP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP. In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates.
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
蛋白家族：

Fic family
數據庫鏈接：

KEGG: rno:288741

UniGene: Rn.162153