Recombinant Mouse Transmembrane protein C20orf123 homolog

in vitro E.coli expression system

中文名稱：

小鼠Ocstamp重組蛋白
貨號(hào)：

CSB-CF880503MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Ocstamp
Uniprot No.：

Q9D611
別名：

Ocstamp; Osteoclast stimulatory transmembrane protein; OC-STAMP
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-498
氨基酸序列

MRTIRAATEHLFGLGWKFWRLGICKAVVPLQAAWKAFSQPVPASCNELLTQLLLCVSLAS LIAGLAHHWLVSLQLYPLGPPALVTSLCGLFVFLSLGLVPPIRCLFVLSVPTLGSKQGRR LLLSYSAANLAVAVVPNVLGNVRAAGQVLSCVTEGSLESLLNTTYQLRQAARELGPASRA GSRSLTFEVEGKGSAFRLHMHTITQEILEDFSGLEFLARAALGTQRVVTGLFLLGLLGES AWYLHRYLTDLRFDNIYATRQLVRQLAQAGATHLLTSPPPWLLQTAQPKLSREELLSCLL RLGLLALLLVATAVTVASDYGAFLLAQAAVAWAQKLPTVPITLTVKYDASYKVLDFILFV LNQPPVESVFASMQRSFQWELRFTPHDCHLPQAQPPRVTAALAAGALQLLAGATLVLQAY AWRLRHTIAASFFPDQEARRLSHLQARLQRRHNQSDHLNKQPGTMATRESRKPGQGTRTL ESQGPQAHDSLGPPYDLE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation.
基因功能參考文獻(xiàn)：
1. Results indicte that oc-stamp may play an important role in macrophage polarization and inhibit the M1 pro-inflammatory state. PMID: 28981605
2. Restoring OC-STAMP in knockout cells by lentiviral transduction rescued fusion and resorption. PMID: 26042409
3. OC-STAMP is a regulatory molecule for FBGCs; and that they are functionally distinct from OCs, despite similarities in gene expression profile, podosome belt formation, and TRAP expression. PMID: 23444125
4. Fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP. PMID: 22337159
5. The osteoclast differentiation needs the coordinated expression of OC-STAMP with several molecules required for transcription, signaling transduction, and cell fusion. PMID: 20882308
6. OC-STAMP is a previously unknown, RANKL-induced, multipass transmembrane protein that promotes the formation of multinucleated osteoclasts. (Osteoclast stimulatory transmembrane protein) PMID: 18064667
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亞細(xì)胞定位：

Membrane; Multi-pass membrane protein.
組織特異性：

Expressed in osteoclast (at protein level). Ubiquitous. Highly expressed in multi-nuclear osteoclast cells compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs).
數(shù)據(jù)庫鏈接：

KEGG: mmu:74614

STRING: 10090.ENSMUSP00000029213

UniGene: Mm.72179