Recombinant Mouse ORM1-like protein 3 (Ormdl3)

in vitro E.coli expression system

中文名稱：

小鼠Ormdl3重組蛋白
貨號：

CSB-CF887413MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Ormdl3
Uniprot No.：

Q9CPZ6
別名：

Ormdl3; ORM1-like protein 3
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-153
氨基酸序列

MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHVVLLSIPFVSVPVVWTLTNLIHNLGM YIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYD QVHFILNTVSLMTVLIPKLPQLHGVRIFGINKY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling.
基因功能參考文獻(xiàn)：
1. Expression levels of ORMDL3, phosphorylated (p)ERK and MMP9 were significantly greater in the asthmamodel group; however, in the group pretreated with budesonide their expression was reduced. PMID: 28358425
2. ORMDL3 mediates the autophagy via the ATF 6-Beclin1 autophagy pathway, and it facilitates the survival of splenic B cells via promoting autophagy and suppressing apoptosis PMID: 28747345
3. ORMDL3 might influence de novo sphingolipid metabolism downstream of serine palmitoyltransferase PMID: 27645259
4. inhibiting ORMDL3 in airway epithelial cells plays a significant role in induction of allergen-induced increases in airway hyperresponsiveness PMID: 28275141
5. ORMDL3, an asthma susceptibility gene identified by genome-wide association studies, contributes to key pathways that promote changes in airway physiology during allergic immune responses. PMID: 27623174
6. Mediated by GATA3 through targeting promoter region of ORMDL3. PMID: 28031110
7. Downregulation of ORMDL3 expression in mast cells enhances AKT and NF-kappaB-directed signaling pathways and chemotaxis and contributes to the development of mast cell-mediated local inflammation in vivo. PMID: 26407610
8. overexpression of ORMDL3 regulates ceramide homeostasis in cells in a complex manner and suggest that local FTY720 administration might be a useful therapeutic intervention for the control of allergic asthma. PMID: 25842287
9. the contribution of ORMDL3 to asthma risk may involve changes in sphingolipid metabolism PMID: 25691431
10. These studies provide evidence that ORMDL3 plays an important role in vivo in airway remodeling potentially through ATF6 target genes. PMID: 24623133
11. ORMDL3 promotes eosinophil trafficking and activation via regulation of CD18, CD49d, and CD48. PMID: 24056518
12. signaling pathway cAMP/PKA/CREB plays an important role in regulating ORMDL3 expression PMID: 23577138
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亞細(xì)胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

ORM family
數(shù)據(jù)庫鏈接：

KEGG: mmu:66612

STRING: 10090.ENSMUSP00000053056

UniGene: Mm.180546