Recombinant Mouse Neuromedin-B receptor (Nmbr)

in vitro E.coli expression system

中文名稱：

小鼠Nmbr重組蛋白
貨號：

CSB-CF015881MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Nmbr
Uniprot No.：

O54799
別名：

Nmbr; Neuromedin-B receptor; NMB-R; Neuromedin-B-preferring bombesin receptor
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區(qū)域：

1-390
氨基酸序列

MPPRSLSNLSFPTEANESELVPEVWEKDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLG NIMLVKIFLTNSAMRNVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIP AIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVLLWTSLKAVGIWVVSVLLAVPEAV FSEVARIGSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLI KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHVLYLYRSFNYKEIDPSL GHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGRKSYPERSTSYLLSSSAV RMTSLKSNTKNVVTNSVLLNGHSTKQEIAL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Receptor for neuromedin-B.
基因功能參考文獻：
1. Neuromedin B expression identifies retrotrapezoid nucleus neurons in the mouse. PMID: 29066557
2. NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2. PMID: 28780306
3. mice with deletion of NB receptor have lower insulinemia, especially in response to oral glucose, and females also exhibited a better glucose tolerance, suggesting the involvement of neuromedin b and its receptor in regulation of insulin secretion induced by incretins, and also, in insulin sensitivity. PMID: 27756093
4. ablating NMB receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially PMID: 26855425
5. The neuromedin B pathways are importantly involved in secretory pathways of TSH and revealed its participation in the in vivo regulation of gene expression of TSH beta-subunit and pituitary MCT8 and Thrb and hypothalamic TRH and type 2 deiodinase. PMID: 25454367
6. Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling. PMID: 25209280
7. spinal GRPr and NMBr independently drive itch neurotransmission in mice. PMID: 23826298
8. Results implicate that NMB is involved in cartilage development, either in an autocrine or paracrine manner. PMID: 22652580
9. The mRNA and protein expressions of NMBR reach a peak at the onset of labor. PMID: 19587437
10. disruption of the neuromedin B receptor pathway did not change body weight homeostasis in female mice fed a normolipid diet PMID: 20211980
11. NMB-R-deficient mice exhibited decreased behavior in both the L-D box and elevated plus maze tests. PMID: 11803457
12. 5-HT expression in the dorsal raphe (DR)nucleus is elevated in NMB-R-deficient mice. NMB/NMB-R may modulate 5-HT neuronal activity by affecting DR function. PMID: 12031854
13. Impaired memory in stressed neuromedin B receptor-deficient mice not consequence of changes in activity, anxiety, or pain response. NMB/NMB-R pathway may have role in regulating stress response via neural system controlling learning and memory. PMID: 12576129
14. NMBR and BRS-3 genes were expressed from embryonic days 13-16 and on multiple postnatal days for lungs PMID: 12959933
15. Selectivity of NMBR for neuromedin B over the gastrin-releasing peptide receptor depends primarily on differences in amino acids in the third extracellular domains of the receptors and in the adjacent upper fifth transmembrane region of the two receptors. PMID: 19628633
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:18101

STRING: 10090.ENSMUSP00000020015

UniGene: Mm.487342