Recombinant Mouse Melatonin receptor type 1A (Mtnr1a)

in vitro E.coli expression system

中文名稱：

小鼠Mtnr1a重組蛋白
貨號：

CSB-CF736807MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Mtnr1a
Uniprot No.：

Q61184
別名：

Mtnr1a; Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-353
氨基酸序列

MKGNVSELLNATQQAPGGGEGGRPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKK LRNSGNIFVVSLAVADLVVAVYPYPLVLTSILNNGWNLGYLHCQVSAFLMGLSVIGSIFN ITGIAMNRYCYICHSLKYDKIYSNKNSLCYVFLIWMLTLIAIMPNLQTGTLQYDPRIYSC TFTQSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWVLVLQVRRRVKPDNKPKLKPQDFRNF VTMFVVFVLFAICWAPLNLIGLIVASDPATMVPRIPEWLFVASYYLAYFNSCLNAIIYGL LNQNFRKEYKKIIVSLCTAKMFFVESSNEEADKIKCKPSPLIPNNNLIKVDSV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
基因功能參考文獻(xiàn)：
1. Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum. PMID: 30043140
2. our data demonstrate that the activation of MT1 signaling at night modulates insulin sensitivity during the day via the regulation of the PI3K transcription and activity PMID: 29247541
3. knockdown of melatonin receptor leads to interference in the normal physiological function of the ovary by enhancing follicular apoptosis, inhibiting proliferation, and influencing hormonal signaling PMID: 29097083
4. the present study shows that MT1 receptor deficiency alters the temporal feeding pattern but not the amount of food ingested, and melatonin signaling mediated through the MT1 receptor stimulates Pro-Opiomelanocortin expression in both the ARC and PD of mice. PMID: 27490331
5. Taken together, these data suggest that melatonin-MT1 receptor complexes represent a potential target for the treatment of glioma. PMID: 29408377
6. Ecto-5'-nucleotidase mRNA levels were found to be diminished in both MT1 and MT1/2 knockout mice. PMID: 26917036
7. The removal of MT1R or MT2R in mice abolished the daily rhythm in blood glucose levels, but produced small effects on the rhythmic expression patterns of clock genes within skeletal muscle, liver, and adipose tissue. PMID: 26824606
8. We have shown that melatonin receptors are expressed in embryonic salivary glands, specifically during salivary gland branching morphogenesis. Melatonin inhibits branching morphogenesis independent of both apoptosis and cell proliferation. PMID: 25876057
9. MT1 melatonin receptors are involved in neural pathways modulating diurnal rhythms of spontaneous behavior in the homecage as well as pathways regulating depressive and anxiolytic-like behaviors. PMID: 25200199
10. These data demonstrate that melatonin MT1 receptor knockout mice recapitulate several behavioral and neurobiological circadian changes. PMID: 25638817
11. The effect of miR-29b on endothelial permeability and apoptosis is mediated through the down-regulation of melatonin receptor 1. PMID: 25131924
12. there is an an increased proinflammatory status of mice deficient in both membrane-bound melatonin receptors reflected by altered activation of MAPK cascades and transcriptional activation of proinflammatory mediators PMID: 25352055
13. This study demonistrated that METH-induced CPP is dependent on time of day and the presence of the MT1 receptor, suggesting a role for melatonin in METH-induced reward. PMID: 24813704
14. Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function. PMID: 24106342
15. These data suggest that melatonin, by acting on MT1 receptors, affects NeuroD expression in the gastrointestinal tract and thus might contribute to circadian regulation in metabolic functions. PMID: 23700151
16. MT1R signaling and BMP-4 actions are mutually augmented, leading to fine-tuning of ACTH production by corticotrope cells. PMID: 23701823
17. Deletion of the MT1 and MT2 melatonin receptors decreases the development and expression of methamphetamine-induced locomotor sensitization during the light period. PMID: 22672659
18. Melatonin does not exhibit its potentiation sleeping time in mice through melatonin 3 receptor. PMID: 21166245
19. molecular behavior of MT1 and MT2 receptor PMID: 22202844
20. decreased viability of retinal ganglion cells observed in Mtnr1a knock-out mice may be a consequence of increased intraocular pressure. intraocular pressure and melatonin signaling should be considered as risk factors for glaucoma. PMID: 21362461
21. Immunohistochemical analysis revealed that during tooth development Mel1aR was expressed in secretory ameloblasts, the cells of the stratum intermedium and stellate reticulum, external dental epithelial cells, odontoblasts, and dental sac cells. PMID: 20372918
22. Investigated the role of the melatonin/melatonin receptor system on clock gene expression using a model of primary neuronal cultures prepared from striatum. PMID: 18798788
23. MT1 receptor is a major transducer of melatonin's actions in the breast, suppressing mammary gland development and mediating the anticancer actions of melatonin through multiple pathways. PMID: 20050373
24. Taken together, MT1 receptor signaling may be important for normal brain and behavioral function. PMID: 16459197
25. MT1 receptor transcripts were localized in photoreceptor cells and in some inner retinal neurons. PMID: 19706469
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:17773

STRING: 10090.ENSMUSP00000069872

UniGene: Mm.5133