Recombinant Mouse Mas-related G-protein coupled receptor member X1 (Mrgprx1)

in vitro E.coli expression system

中文名稱：

小鼠Mrgprx1重組蛋白
貨號：

CSB-CF817224MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Mrgprx1
Uniprot No.：

Q8CIP3
別名：

Mrgprx1; Mrgc11; Mrgprc11; Mas-related G-protein coupled receptor member X1; Mas-related G-protein coupled receptor member C11; Sensory neuron-specific G-protein coupled receptor 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-322
氨基酸序列

MDPTISSHDTESTPLNETGHPNCTPILTLSFLVLITTLVGLAGNTIVLWLLGFRMRRKAI SVYILNLALADSFFLCCHFIDSLLRIIDFYGLYAHKLSKDILGNAAIIPYISGLSILSAI STERCLCVLWPIWYHCHRPRNMSAIICALIWVLSFLMGILDWFSGFLGETHHHLWKNVDF IITAFLIFLFMLLSGSSLALLLRILCGPRRKPLSRLYVTIALTVMVYLICGLPLGLYLFL LYWFGVHLHYPFCHIYQVTAVLSCVNSSANPIIYFLVGSFRQHRKHRSLKRVLKRALEDT PEEDEYTDSHLHKTTEISESRY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Orphan receptor activated by neuropeptides terminating in Arg-Phe or Arg-Phe-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception.
基因功能參考文獻：
1. SLIGRL-amide inhibits influenza A virus infection independently of MRGPRC11 and independently of capsaicin-sensitive, neuropeptide-releasing sensory nerves. PMID: 27215903
2. Der p1 also induced the release of IL-6 from heterologous cells expressing MRGPRX1. In summary, activation of Mrgprs by the allergen Der p1 may contribute to inflammation. PMID: 28768771
3. Cathepsin S activates MrgprC11 and evokes receptor-dependent scratching in mice. PMID: 26216096
4. Results suggest that activation of MrgC11 may inhibit high-voltage-activated calcium current in mouse dorsal root ganglion neurons through a voltage-independent mechanism that involves activation of the phospholipase C, but not Galphai or Galphas, pathway PMID: 26022362
5. Mouse bone marrow-derived mast cells express the MrgC11 receptor agonist, RF-amide precursor gene proneuropeptide FF. PMID: 18250432
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family, Mas subfamily
組織特異性：

Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons.
數據庫鏈接：

KEGG: mmu:404242

STRING: 10090.ENSMUSP00000091954

UniGene: Mm.354955