Recombinant Mouse GTPase IMAP family member 1 (Gimap1)

in vitro E.coli expression system

中文名稱：

小鼠Gimap1重組蛋白
貨號：

CSB-CF009420MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Gimap1
Uniprot No.：

P70224
別名：

Gimap1; Ian2; Imap1; Imap38; GTPase IMAP family member 1; Immune-associated protein 38; IAP38; Immunity-associated protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-277
氨基酸序列

MPQLRLILVGRTGTGKSATGNSILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPRTDPGCVETARCFVLSAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDSLQDYVHCTDNRALRDLVAECGGRVCALNNRATGSEREAQAEQLLGMVACLVREHGGAHYSNEVYELVQDTRCADPQDQVAKVAEIVAERMQRRTRLLAGLWGWRKFYWKGWRRGFSVFLGVAILIYLLFYRKGFGDQNNR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells.
基因功能參考文獻：
1. This study shows that GIMAP1 is critical for maintaining the peripheral T-cell pool in mice and offers a potent target for the treatment of T-cell-mediated diseases. PMID: 27792288
2. The data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state. PMID: 26621859
3. These findings show a vital requirement for GIMAP1 in mature lymphocyte development/survival PMID: 20194894
4. The model of up-regulation of GIMAP1 in response to infection/immunization with P. chabaudi is not a robustly reproducible experimental system. PMID: 19338674
亞細(xì)胞定位：

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein.
蛋白家族：

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
組織特異性：

Expressed in thymus, spleen (in splenocytes), lymph node and lung. Detected in mature B-cells and thymocytes (at protein level).
數(shù)據(jù)庫鏈接：

STRING: 10090.ENSMUSP00000062108

UniGene: Mm.252599