Recombinant Mouse Brain protein 44 (Brp44)

in vitro E.coli expression system

中文名稱：

小鼠Mpc2重組蛋白
貨號：

CSB-CF002816MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Mpc2
Uniprot No.：

Q9D023
別名：

Mpc2; Brp44; Mitochondrial pyruvate carrier 2; Brain protein 44
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-127
氨基酸序列

MAAAGARGLRATYHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADM ARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQE LKSKGIQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates the uptake of pyruvate into mitochondria.
基因功能參考文獻：
1. Inhibition of pyruvate metabolism by tolylfluanid required MPC2. PMID: 29126303
2. The interaction between TZDs and MPC2 is not affected by loss of the N-terminal 16 amino acid. PMID: 28597936
3. MPC2 acetylation is increased in Diabetic Heart mitochondria. This study supports the conclusion that deficient pyruvate transport activity, mediated in part by acetylation of MPC2, is a contributor to metabolic inflexibility in the diabetic heart. PMID: 28154187
4. Oxidative glutaminolysis supports the TCA cycle in mouse cells lacking MPC1/2. PMID: 25458843
亞細胞定位：

Mitochondrion inner membrane; Multi-pass membrane protein.
蛋白家族：

Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
數據庫鏈接：

KEGG: mmu:70456

STRING: 10090.ENSMUSP00000027853

UniGene: Mm.195625