Recombinant Mouse Beta-tectorin (Tectb)

中文名稱：

小鼠Tectb重組蛋白
品名簡稱：

Recombinant Mouse Tectb protein
貨號：

CSB-CF023371MO
說明書：

MSDS Datasheet
規(guī)格：

￥5028
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Tectb
Uniprot No.：

O08524
別名：

Tectb; Beta-tectorin
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

in vitro E.coli expression system
分子量：

36.5kDa
表達區(qū)域：

18-305aa
氨基酸序列

KSCTPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDSTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSTKKEAPFVLETSEIGSDLFAGVEAKGLSVRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGKDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVNCDKRKRMLRDQTGGVLVVELSLRSRA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產(chǎn)品描述：

The cDNA fragment encoding 18-305aa of Mouse Beta-tectorin/Tectb was fused with an N-terminal 6xHis-tag and then expressed in vitro E.coli expression system. The product obtained is the Recombinant full-length of mature Mouse Tectb protein. Its purity was determined by using SDS-PAGE and reached up to 90%. On the reducing SDS-PAGE gel, there presented a molecular mass band of about 38 kDa. The slightly higher result was attributed to glycosylation. This recombinant Tectb protein may be used for specific antibody production or on the studies of the tectorial membrane (TM).

Tectb is a non-collagenous glycoprotein localized to the TM. It is exclusively highly expressed in the inner ear. The absence of Tecb impairs TM's core structure and significantly alters the cochlear function. Remarkable sensitivity and exquisite frequency selectivity are hallmarks of mammalian hearing. Roozbeh Ghaffari etc. demonstrated that Tectb mutation-mediated the reduction of the spatial extent and propagation velocity of TM traveling waves is probably responsible for all the hearing abnormalities related to the mutation. The deletion of the tectb gene in the mouse model showed reduced sensitivity and sharper frequency selectivity.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.
數(shù)據(jù)庫鏈接：

KEGG: mmu:21684

STRING: 10090.ENSMUSP00000025936

UniGene: Mm.42139