Recombinant Human Uncharacterized protein C4orf52 (C4orf52)

in vitro E.coli expression system

中文名稱：

人SMIM20重組蛋白
貨號：

CSB-CF843271HU
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

SMIM20
Uniprot No.：

Q8N5G0
別名：

SMIM20; C4orf52; MITRAC7; Small integral membrane protein 20; Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa; MITRAC7
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-168
氨基酸序列

MVKEVWRVLREEPGRRKESRQNRARGNRVQQNSSNLNPTPAPGPHSTESRGRRRAGSEAP PRPGSESLSTSSERGHGPAVGNLVSESAGRSAGQGSPGPDAMSRNLRTALIFGGFISLIG AAFYPIYFRPLMRLEEYKKEQAINRAGIVQEDVQPPGLKVWSDPFGRK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C. Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover.; Peptide involved in a broad spectrum of regulatory functions. Is a ligand for GPR173. As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone. Plays a protective role in memory retention through activation of GNRHR. Regulates the secretion of AVP by hypothalamic neurons. Plays a role in the transduction of the itch sensation. Induces anxiolytic effects, reducing behavior associated with anxiety. Regulates food intake as well as satiation and satiety. In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR. It also increases the production of estradiol (E2). In the heart, it regulates contractility and relaxation. It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways. Stimulates the proliferation and differentiation of preadipocytes. In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS.; Peptide involved in a broad spectrum of regulatory functions. Is a ligand for GPR173. As part of the reproductive cycle, it regulates gonadotropin-releasing hormone (GnRH) signaling in the hypothalamus and pituitary gland which augments the release of luteinizing hormone. Plays a protective role in memory retention through activation of GNRHR. Regulates the secretion of AVP by hypothalamic neurons. Plays a role in the transduction of the itch sensation. Induces anxiolytic effects, reducing behavior associated with anxiety. Regulates food intake as well as satiation and satiety. In the ovary, it regulates follicular growth by stimulating granulosa cell proliferation by increasing the expression of GPR173, CREB1, CYP19A1, KITLG, FSHR, and LHCGR. It also increases the production of estradiol (E2). In the heart, it regulates contractility and relaxation. It also plays a cardioprotective role during ischemia, where it activates the SAFE and RISK pathways. Stimulates the proliferation and differentiation of preadipocytes. In pancreatic islet cells, it induces proliferation of islet cells as well as the production of INS.
基因功能參考文獻：
1. MITRAC7 affects the biogenesis pathway by stabilizing newly synthesized COX1 in assembly intermediates, concomitantly preventing turnover. PMID: 26321642
2. SMIM20 (MITRAC7) is a COX1 specific chaperone which is necessary for cytochrome c oxidase biogenesis. PMID: 26321642
亞細胞定位：

[Small integral membrane protein 20]: Mitochondrion inner membrane; Single-pass membrane protein.; [Phoenixin-14]: Secreted.; [Phoenixin-20]: Secreted.
組織特異性：

Expressed in the ovary, specifically in granulosa cells of follicles that have passed the primary stage and in oocytes (at protein level).
數據庫鏈接：

HGNC: 37260

OMIM: 617465

KEGG: hsa:389203

STRING: 9606.ENSP00000427407

UniGene: Hs.479386