Recombinant Human Tetraspanin-7 (TSPAN7)

中文名稱：

Recombinant Human Tetraspanin-7 (TSPAN7)
品名簡稱：

Recombinant Human TSPAN7 protein
貨號：

CSB-CF025165HU(A4)
說明書：

MSDS Datasheet
規格：
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

TSPAN7
Uniprot No.：

P41732
別名：

Cell surface glycoprotein A15;Membrane component chromosome X surface marker 1;T-cell acute lymphoblastic leukemia-associated antigen 1;Transmembrane 4 superfamily member 2
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

in vitro E.coli expression system
分子量：

30.6 kDa
表達區域：

1-249aa
氨基酸序列

MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTLGTYISLIAENSTNAPYVLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTDAMQTYNGNDERSRAVDHVQRSLSCCGVQNYTNWSTSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANQYEMV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May be involved in cell proliferation and cell motility.
基因功能參考文獻：
1. These results disclosed a previously uncharacterized role of TSPAN7 in the regulation of the expression and functional activity of DRD2 by postendocytic trafficking. PMID: 28223337
2. The role of TSPAN7 in immune system response to HIV-1 is reviewed. TSPAN7 appears to be a positive regulator of actin nucleation and stabilization, through the ARP2/3 complex. By doing so, TSPAN7 limits HIV-1 endocytosis and maintains viral particles on actin-rich dendrites for an efficient transfer toward T lymphocytes. PMID: 28620031
3. Elevated TSPAN7 may be associated with better outcomes for multiple myeloma patients. PMID: 25637218
4. Loss of TSPAN7 is associated with metastasis in clear-cell renal cell carcinoma. PMID: 22213152
5. This study identified that TSPAN7 as a key molecule for the functional maturation of dendritic spines via PICK1 and ampa receptor trafficking. PMID: 22445342
6. TM4SF2 was identified as a putative antigenic target in Wegener's granulomatosis PMID: 20951001
7. Studies indicate that The thymus leukemia (TL) antigen and CD8alphaalpha are interacting surface molecules that are expressed at the frontline of the mucosal immune system. PMID: 20850477
8. The interaction of VP26 with tetraspanin-7 plays an essential role in normal HSV-1 replication. PMID: 20630051
9. associated with spermatozoa PMID: 19535787
10. The role of TMSF2 in mental retardation PMID: 14735593
11. coding mutations in TSPAN7 are not associated with our cohort of autism patients PMID: 19339915
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相關疾病：

Mental retardation, X-linked 58 (MRX58)
亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Tetraspanin (TM4SF) family
組織特異性：

Not solely expressed in T-cells. Expressed in acute myelocytic leukemia cells of some patients.
數據庫鏈接：

HGNC: 11854

OMIM: 300096

KEGG: hsa:7102

STRING: 9606.ENSP00000367743

UniGene: Hs.441664