Recombinant Human Metalloreductase STEAP4 (STEAP4)

in vitro E.coli expression system

中文名稱：

人STEAP4重組蛋白
貨號：

CSB-CF731557HU
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

STEAP4
Uniprot No.：

Q687X5
別名：

STEAP4; STAMP2; TNFAIP9; Metalloreductase STEAP4; Six-transmembrane epithelial antigen of prostate 4; SixTransMembrane protein of prostate 2; Tumor necrosis factor, alpha-induced protein 9
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-459
氨基酸序列

MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPS GAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEY LAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQ GSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAI SIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGF AFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFV LLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAY VLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation.
基因功能參考文獻：
1. These findings suggest that increased STEAP4 mRNA expression is associated with inflammatory stimuli, whereas lower STEAP4 expression is associated with obesity in human islets. PMID: 28405880
2. STEAP4 plays role in metal homeostasis is critical to the maintenance of cellular homeostasis , and in preventing the onset of metabolic disease. [review] PMID: 28576871
3. a down regulation of STEAP4 and up-regulation of HIF-1alpha are observed in morbidly obese patients PMID: 27058639
4. The expression of TNFAIP9 significantly decreased in the adipose tissue of obese children, and its levels are closely related to blood lipid level, insulin resistance, and obesity. PMID: 27706555
5. the expression of STEAP4 was significantly downregulated in the adipose tissue of obese children. PMID: 27808366
6. Some SNPs of the STEAP4 gene altered the risk of developing a metabolic syndrome in the Han Chinese population. PMID: 26510124
7. These data suggest that STAMP2 is required for prostate cancer progression and thus may serve as a novel therapeutic target. PMID: 25680860
8. may interact with mitochondria [review] PMID: 24643198
9. Our results show increased mRNA expression of STEAP4 and NGAL in human visceral adipose tissue in obese patients. PMID: 23179203
10. Our findings revealed that STAMP2 gene polymorphisms are likely to significantly contribute to the risk of MetS in male Han Chinese population. PMID: 23953178
11. three polymorphisms (rs8122, rs1981529 and rs34741656) of STAMP2 gene may be not related with type 2 diabetes mellitus in Xinjiang Uygur population PMID: 23134829
12. STEAP4 was highly induced in human adipose cells differentiated in the presence of 1,25D. PMID: 23553608
13. STAMP2 antagonizes HBx-mediated hepatocyte dysfunction, thereby protecting hepatocytes from hepatitis B virus gene expression. PMID: 23095254
14. STEAP4 genetic variations are likely to be associated with obesity-related insulin resistance in Uygur Chinese general population. PMID: 21718614
15. STEAP4 is expressed on monocytes and neutrophils in peripheral blood of patients with rheumatoid arthritis. PMID: 22244520
16. STEAP4 might potentially suppress the pathogenesis of TNFalpha-induced arthritis such as rheumatoid arthritis. PMID: 21633911
17. an association of the common variation rs1981529 (Gly75Asp, 224A/G) in the STEAP4 gene with obesity in Uygur general population PMID: 21933608
18. Decreased STAMP2 expression (mRNA and protein) might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes. PMID: 21849520
19. The knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via the attenuated phosphorylation of Akt, independent of the effects of EEA1. PMID: 21468601
20. There was no association of the three polymorphisms (rs8122, rs1981529 and rs34741656) in the STAMP2 gene with essential hypertension in Xinjiang Uygur population. PMID: 21287513
21. STEAP 4 genetic polymorphisms may be associated with metabolic syndrome risk in Chinese Uygur population. PMID: 21287516
22. Fourteen novel and six known single nucleotide polymorphisms (SNPs) including 2 nonsynonymous SNPs in the STEAP4 gene were identified. SNPs rs8122 and rs1981529 were significantly associated with the metabolic syndrome phenotype in females. PMID: 21044749
23. common polymorphisms of STAMP2 are unlikely to significantly contribute to the risk of the metabolic syndrome in the general population PMID: 20382686
24. Results demonstrate that STEAP4 does not influence human adipocyte differentiation, but it participates in regulating the insulin sensitivity of human adipocytes. PMID: 20127040
25. Human WAT STAMP2 associates with obesity and insulin resistance independently of adiponectin. PMID: 18381574
26. Down-regulation of STEAP4 is associated with obesity in humans. PMID: 18430367
27. TIARP/STAMP2 is highly upregulated in 3T3-L1 cells and hMSC-Ad by IL-1beta and might, therefore, modulate proinflammatory and insulin resistance-inducing effects of IL-1beta. PMID: 19289123
28. STEAP4 associates with focal adhesion kinase (FAK) and regulate the activity of FAK through Y397 phosphorylation. PMID: 19787193
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亞細胞定位：

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
蛋白家族：

STEAP family
組織特異性：

Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and
數據庫鏈接：

HGNC: 21923

OMIM: 611098

KEGG: hsa:79689

STRING: 9606.ENSP00000369419

UniGene: Hs.521008