Recombinant Human Membrane-associated progesterone receptor component 1 (PGRMC1)

in vitro E.coli expression system

中文名稱：

人PGRMC1重組蛋白
貨號(hào)：

CSB-CF017876HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

PGRMC1
Uniprot No.：

O00264
別名：

PGRMC1; HPR6.6; PGRMC; Membrane-associated progesterone receptor component 1; mPR; Dap1; IZA
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-195
氨基酸序列

AAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.
基因功能參考文獻(xiàn)：
1. High PGRMC1 expression is associated with renal cell carcinoma. PMID: 30015972
2. Down-regulation of PGRMC1 was associated with poor tumor differentiation and worse patient survival in hepatocellular carcinoma. PMID: 29563759
3. These new findings demonstrate that PGRMC1 might play an important role in progression and therapy resistance of human breast tumors and could offer an interesting target for anticancer therapy. PMID: 28701017
4. Cystathionine beta-synthase and PGRMC1 function as carbon monoxide sensors in health and disease. (Review) PMID: 27565814
5. Sigma-2 receptor and PGRMC1 are not identical. PMID: 28007569
6. Report a dynamic pattern of PGRMC1 and SERBP1 expression in human endometrium throughout the menstrual cycle and highlight a putative novel implication of PGRMC1 in the human decidualization process. PMID: 28911927
7. Progesterone, Inflammatory Cytokine (TNF-alpha), and Oxidative Stress (H2O2) Regulate Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Fetal Membrane Cells. Study concludes that these stimuli act as regulatory factors of PGRMC1 in a cell-specific manner. PMID: 26919974
8. findings demonstrate PGRMC1, which promotes RCC progression phenotypes in vitro and in vivo, is a novel potential biomarker and therapeutic target for RCC PMID: 28107520
9. Data suggest that PGRMC1 plays important roles in synthesis of cholesterol and steroids and in energy regulation. [REVIEW] PMID: 28104494
10. data illustrate a role for PGRMC1 in regulating heme synthesis via interactions with FECH and suggest that PGRMC1 may be a heme chaperone or sensor PMID: 27599036
11. The effects of progesterone treatment on the expression levels of progesterone receptor membrane component 1 (PGRMC1), plasminogen activator inhibitor 1 RNA-binding protein (PAIRBP1), and progestin and adipoQ receptor 7 (PAQR7) on both mRNA and protein levels were investigated in spheroids derived from human glioma cell lines U-87 MG and LN-229. PMID: 27340667
12. It can be suggested that women with breast epithelium highly expressing PGRMC1 and in interaction with ERalpha may have an increased risk to develop breast cancer. PMID: 26303031
13. These results clarify that PGRMC1 and the S2R are distinct binding sites expressed by different genes. PMID: 26870805
14. Haem-mediated PGRMC1 dimerization is required for interactions with EGFR and cytochromes P450, cancer proliferation and chemoresistance against anti-cancer drugs. PMID: 26988023
15. indicate that PGRMC1 regulates hepcidin gene expression through an evolutionarily conserved mechanism PMID: 26657863
16. results suggested that PGRMC1 and sigma2 receptors are two different molecular entities. PMID: 25843410
17. PGRMC1 is the major progesterone receptor eliciting the protective effects of Norgestrel, a synthetic female progesterone hormone. PMID: 26447367
18. coding mutations of PGRMC1 do not seem to be a common cause of the disease in Han Chinese PMID: 25246111
19. PGRMC1 overexpression led to the epithelial-mesenchymal transition and chemoresistance in uterine sarcoma. PMID: 25596698
20. progesterone binds to hPGRMC1 and introduces spectral changes that manifest conformational changes to the heme. PMID: 25675345
21. Loss of PGRMC1 expression is associated with endometrial tumor cell viability during chemotherapeutic stress. PMID: 25304370
22. PGRMC1 binds to key components of the autophagy machinery and is required for the degradative activity of autophagy PMID: 24113030
23. PGRMC1 expression appears to be diminished in pregnant women with preterm premature rupture of the membranes. PMID: 24680695
24. PGRMC-1 expression is downregulated in the endometria from women with advanced stage endometriosis. PMID: 23793472
25. In a chorion cell line, PGRMC1 mediates the effects of progestins on matrix metalloproteinase 9 activity. PMID: 23813454
26. PGRMC1 can act as an adaptor protein for multiple classes of steroid receptors PMID: 24424068
27. ABHD5, PGRMC1 and SQS are novel markers for sebaceous carcinoma and can reliably distinguish sebaceous neoplasms from non-sebaceous tumors, specifically BCC with clear cell features. PMID: 23557589
28. The expression of PGRMC1 is strongly associated with the progression of breast cancer. PMID: 22588913
29. Data suggest that women with breast cells overexpressing PGRMC1 have higher risk of breast cancer when treated with progestins (as in some hormonal contraceptives). PMID: 23116217
30. miR-98 and miR-181a through their regulatory functions on PGRMC1, PGR, CYP19A1, TIMP3, and DDX3X expression may influence a wide range of endometrial cellular activities during normal menstrual cycle and transition into disease states. PMID: 22492871
31. Pgrmc1 localizes to secretory vesicles in cancer cells, and Pgrmc1 was secreted by lung cancer cells. Furthermore, Pgrmc1 was significantly elevated in the plasma of lung cancer patients compared to noncancer patients. PMID: 21918976
32. PGRMC1 negatively modulates the drug-metabolizing activities of P450. PMID: 21825115
33. In patients with elevated PGRMC1 mRNA levels, gonadotropin-induced follicle development is attenuated, although sufficient numbers of follicles develop to allow for embryo and subsequent pregnancy. PMID: 22245528
34. roles of progesterone (P4) and Progesterone Receptor Membrane Component 1 (PGRMC1) in regulating mitosis of ovarian cancer cells, SKOV-3. P4's actions appear to be dependent on PGRMC1's function within the mitotic spindle. PMID: 21148105
35. Expression of PGRMC1 mRNAs was significantly lower in JEG-3 cells compared to non-syncytialized BeWo cells. PMID: 21455559
36. PGRMC1 is lower in myometrium of women at term either not in labour (P = 0.004) or in labour (P = 0.005) compared with tissues from women in preterm non-labour. PMID: 21131300
37. we propose that PGRMC1 expression is regulated by the miRNAs let-7/miR-98 PMID: 21109987
38. Reduced levels of PGRMC1 in peripheral leukocytes are associated with perturbed ovulatory function. PMID: 20537145
39. Pgrmc1 associates with epidermal growth factor receptor and regulates erlotinib sensitivity PMID: 20538600
40. increases in vivo tumor growth, anchorage-independent growth, and migration PMID: 20164297
41. Hpr6.6 regulates cell death through a novel oxidative damage response pathway. PMID: 14523988
42. The expression of a novel progesterone-binding protein (hmPR2/PGMRC2) was investigated. Transcripts of this protein have been detected in human sperm. PMID: 15702432
43. Hpr6 homologues regulate cytochrome P450 proteins implicated in hormone, steroid and xenobiotic chemical metabolism; Hpr6 expression linked to cancer progression and cellular survival PMID: 15970648
44. Our findings support a model in which Hpr6 binds to heme and regulates susceptibility to damaging agents PMID: 16234411
45. These findings demonstrate that PGRMC1 is required for P450 activity and suggest that interindividual variation in PGRMC1 function may impact multiple biochemical pathways and drug metabolism. PMID: 17276356
46. PGRMC1 may be involved in sterol metabolism or homeostasis and cell survival [review] PMID: 18249431
47. PGRMC1 plays an important role in promoting ovarian cancer cell viability and that attenuating PGRMC1's action makes the ovarian cancer cells more sensitive to cisplatin. PMID: 18319313
48. The aim of this study was to assess the expression, localization and hormonal regulation of two novel P(4) receptor candidates, P(4) receptor membrane component (PGRMC) 1 and PGRMC2, as well as the PGRMC1 partner Serpine 1 mRNA binding protein (SERBP1). PMID: 18440126
49. The results demonstrate the first demonstration of mPR expression in human epithelial ovarian tumors. PMID: 18479732
50. These findings suggest that mutant or reduced levels of PGMRC1 may cause premature ovarian failure through impaired activation of the microsomal cytochrome P450 and increased apoptosis of ovarian cells. PMID: 18782852
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亞細(xì)胞定位：

Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side.
蛋白家族：

Cytochrome b5 family, MAPR subfamily
組織特異性：

Widely expressed, with highest expression in liver and kidney. Expressed by endometrial glands and stroma (at protein level).
數(shù)據(jù)庫(kù)鏈接：

HGNC: 16090

OMIM: 300435

KEGG: hsa:10857

STRING: 9606.ENSP00000217971

UniGene: Hs.90061