Recombinant Human 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)

in vitro E.coli expression system

中文名稱：

人HSD17B2重組蛋白
貨號：

CSB-CF010772HU
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

HSD17B2
Uniprot No.：

P37059
別名：

HSD17B2; EDH17B2; SDR9C2; 17-beta-hydroxysteroid dehydrogenase type 2; 17-beta-HSD 2; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Estradiol 17-beta-dehydrogenase 2; Microsomal 17-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C member 2; Testosterone 17-beta-dehydrogenase
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-387
氨基酸序列

MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.
基因功能參考文獻：
1. ATRA treatment decreased the mRNA expression of 17-beta-dehydrogenase 2 (HSD17B2) which converts estradiol into estrone in a dose-dependent manner PMID: 26228249
2. Our findings suggested that CYP19A1 and HSD17B2 polymorphisms might be associated with circulating sex hormone levels in Japanese postmenopausal women, independent of current BMI. PMID: 26323233
3. Data indicate that conversion of testosterone to 4-dione detected in abdominal adipose tissue is caused by 17b-HSD type 2 which is localized in the vasculature of the adipose compartment. PMID: 26123590
4. This study demonstrated that HSD17B2 transcript and protein levels are linked to some clinicopathological features in gastric cancer. PMID: 25776474
5. In both arm and subumbilical skin biopsy of patients with idiopathic hirsutism, there was an up-regulation of HSD17B2 mRNA expression. PMID: 26194504
6. Single nucleotide polymorphism in HSD17B2 gene is associated with hepatocellular carcinoma. PMID: 24563232
7. This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression PMID: 24682418
8. SNP variants in the 17beta-HSD2 and 17beta-HSD7 genes and 17beta-HSD7 copy number is associated with increased estradiol levels in breast cancer tissues. PMID: 24560990
9. overexpression of 17beta-HSD2 in sebocytes significantly increased the androstenedione production and markedly decreased the amounts of testosterone and dihydrotestosterone PMID: 24938708
10. no significant difference in the genotype and allele frequencies of rs8191246 between uterine leiomyoma cases and controls PMID: 22546946
11. Single-nucleotide polymorphisms in HSD17B2, HSD17B3 and HSD17B1 are associated with plasma testosterone level and prostate cancer aggressiveness. PMID: 21900597
12. Data indicate that 17betaHSD2 expression is higher in HUAEC than in HUVEC; activity is higher in umbilical arteries near the placenta. These data are consistent with higher sex steroid inactivation in the arterial system of the foeto-placental unit. PMID: 21877158
13. Data show that steroidogenic enzymes (AKR1C3, HSD17B2, UGT2B15 and UGT2B17) and stem/progenitor cell markers CK5 and ABCG2 were upregulated in castration resistant prostate cancer. PMID: 21365123
14. Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2. PMID: 11940569
15. Androgen inactivation in human lung fibroblasts: variations in levels of 17 beta-hydroxysteroid dehydrogenase type 2 PMID: 12161528
16. the lower expression of type 2 17 beta-HSD mRNA in scalp hairs of untreated hirsute patients suggests androgen metabolism disturbances with predominance of more potent androgens PMID: 12957669
17. 17HSD type 2 mRNA expression in gastric mucosa of children compared to adults may be associated with increased need for protection against the mucosal load of foreign substances. The downregulation may have relevance in the pathogenesis of gastric cancer. PMID: 14666693
18. Aromatase mRNA was higher in epithelial than in stromal cells in eutopic and ectopic endometrium in endometriosis. 17betaHSD2 in epithelial cells was increased during secretory phases compared with late proliferative phase. PMID: 16595205
19. HSD17B2 expression in endometrial epithelial cells, and, therefore, estrogen inactivation, is regulated by SP1 and SP3, which are downstream targets of progesterone-dependent paracrine signals originating from endometrial stromal cells. PMID: 16807381
20. importance of 17HSD type 2 in breast cancer- cell lines & non-tumour breast cells; high or low expression of 17HSD type 2 affected oestradiol concentration significantly; response was dependent on endogenous expression of 17HSD type 1 PMID: 16954436
21. Previously unknown polymorphism was found in exon four of HSD17B2. Polymorphism does not contribute to a higher risk of developing breast cancer. PMID: 17260097
22. The expression of 17beta-hydroxysteroid dehydrogenase type 2 (17beta-HSD2) in eutopic and ectopic endometrial tissues of women with endometriosis is reported. PMID: 17505937
23. role for HSD17B2 in the action of retinoids, in addition to its oxidative HSD17B activity on sex steroids PMID: 17510238
24. Data reported that a similar level of 17beta-hydroxysteroid dehydrogenase type 2 mRNA was found in Polycystic Ovary Syndrome and the control tissues. PMID: 17953976
25. Overexpression in African-American breast cancer may contribute to the increased proportion of estrogen receptor-negative breast cancers and worse clinical outcome among African-American patients. PMID: 17993718
26. The bone development in transgenic male mice ubiquitously expressing human HSD17B2, was studied. PMID: 18348690
27. HSD17B2 germline mutations potentially involved in breast cancer predisposition. PMID: 18372405
28. 17beta-HSD type 2 was expressed in 20% of breast cancer specimens. decrease in 17beta-HSD type 2 expressions in breast cancer may play a role in the development &/or progression of cancer by modifying the intratumoral levels of estrogens & androgens. PMID: 18996480
29. preference of 17betaHSD2 for E2 oxidation strongly resists alteration by genetic & metabolic means. Findings suggest additional structural features, beyond lack of a specific Arg residue, disfavor NADPH binding & thus support E2 oxidation by 17betaHSD2 PMID: 19556422
30. BRCA1 and HSD17B2 genes may increase the risk of developing breast cancer via enhanced estradiol activity. PMID: 19729830
31. HSD17B2 modulates estrogen-independent and estrogen-dependent action in transgenic female mice. PMID: 19797119
32. HSD17B2 mRNA is expressed in human skin, at higher levels in men than in women. Expression levels vary with skin sites. HSD17B2 levels are not altered by topical 17-beta-estradiol treatment. PMID: 18794456
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亞細胞定位：

Membrane; Single-pass type II membrane protein.
蛋白家族：

Short-chain dehydrogenases/reductases (SDR) family
組織特異性：

Expressed in placenta.
數據庫鏈接：

HGNC: 5211

OMIM: 109685

KEGG: hsa:3294

STRING: 9606.ENSP00000199936

UniGene: Hs.162795