Recombinant E3 ubiquitin-protein ligase hrd-1 (sel-11)

in vitro E.coli expression system

中文名稱：

秀麗隱桿線蟲sel-11重組蛋白
貨號：

CSB-CF635313CXY
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

sel-11
Uniprot No.：

Q20798
別名：

sel-11; hrd-1; F55A11.3; E3 ubiquitin-protein ligase hrd-1; RING-type E3 ubiquitin transferase hrd-1; Suppressor/enhancer of lin-12
種屬：

Caenorhabditis elegans
蛋白長度：

Full Length of Mature Protein
表達區域：

24-610
氨基酸序列

FLINKQFYPSIVYLSKSNASMAVIYVQGIVLVYLMFQLLKSILFGDLRAAEAEHLSERTW HAVLETCLAFTVFRDDFSAIFVMQFIGLLFIKCFHWLADDRVDMMERSPVITLRFHLRMM TVLAALGFADSYFVSSAYFTTITRGASAQIVFGFEYAILLALVLHVTIKYLLHMHDLRNP QSWDNKAVYLLYAELFINLIRCLLYGFFAVVMLRVHTFPLFSVRPFYQSVRALHKAFLDV ILSRRAINAMNSQFPVVSAEDLAAMDATCIICREEMTVDASPKRLPCSHVFHAHCLRSWF QRQQTCPTCRTDIWQGRNGAAAGGNAADAAANVADANVAGAQIGAGMPPFLPFLGHQFGF PQQPAGAGGAQPGAAQAGGQPGPFPHQIFYAPAPANRPEFMNLIPPPPLPMAGPPGMFPM MPPPPLPQVNTTQGTSSETPPVNPSYSQLSTEELRRMEGESREALLARLQAMDNIMVLLE SAQMQMIQLATVTPIRPRPVVPSDESEQEAPGPSTDQVTSEEQEIPATSSAPSIFRTESP STSSTAPSTSSPVTASSTPTTSSTRTPEAEEVRQRRLARLLGENANQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play a role together with hsp-3 in developmental growth and function of intestinal cells and to play a role together with hsp-4 in gonad formation.
基因功能參考文獻：
1. HRD-1 play essential roles in unfolded protein response (UPR) and ERAD pathways. We further found that HRD-1 functions in concert with BiP. PMID: 17825049
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

HRD1 family
數據庫鏈接：

KEGG: cel:CELE_F55A11.3

STRING: 6239.F55A11.3.1

UniGene: Cel.23482