Recombinant Drosophila melanogaster Putative phosphatidate phosphatase (wun)

in vitro E.coli expression system

中文名稱：

黑腹果蠅wun重組蛋白
貨號：

CSB-CF893233DLU
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

wun
Uniprot No.：

Q9V576
別名：

wun; CG8804; Putative phosphatidate phosphatase; Germ cell guidance factor; Phosphatidic acid phosphatase type 2; Protein wunen
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

full length protein
表達區域：

1-379
氨基酸序列

MPAVKIIMSTETSASETTPLRRSENETPDHKELAQSNSNSRQTTVNSNNNNYSNSVQVRL QEQDRDSDSEQQQHTATITMDTNKRILCRVGLDVLILLCAGFPILLFFLLGEPYKRGFFC DDESLKHPFHDSTVRNWMLYFIGAVIPVGVIFIVEVIISQNKAKQDNGNATSRRYVFMNY ELPDWMIECYKKIGIYAFGAVLSQLTTDIAKYSIGRLRPHFIAVCQPQMADGSTCDDAIN AGKYIQEFTCKGVGSSARMLKEMRLSFPSGHSSFTFFAMVYLALYLQARMTWRGSKLLRH LLQFLFIMVAWYTALSRVSDYKHHWSDVLAGSLIGSISALVVANYVSDLFQKPNTKPYLA RTVQDMNASPAQAITITTN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Responsible for guiding the germ cells early in the process of migration from the lumen of the developing gut towards the overlying mesoderm, where the germ cells enter the gonads. May be involved in lipid metabolism.
基因功能參考文獻：
1. Wunen mutants have cardioblast joining defects and loose pericardial cells in the developing heart. PMID: 25224224
2. The germ cell migratory path can be primarily accounted for by Wunen expression. PMID: 24006260
3. germ cell survival and directionality of migration are controlled by two lipid phosphate phosphatases (LPP), wunen (wun) and wunen-2 (wun2). wun wun2 double mutant analysis reveals that the two genes act redundantly in primordial germ cells. PMID: 20431117
4. there are marked differences in biochemical activity between fly Wun and mammalian lipid phosphate phosphatase (LPPs), with Wun having a narrower activity range than has been reported for the mammalian LPPs PMID: 12856002
5. Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2 have roles in lateral migration and germ cell elimination PMID: 16301333
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

PA-phosphatase related phosphoesterase family
組織特異性：

Expressed in embryonic gut in a pattern that guides germ cells towards mesoderm (initially in hindgut and then on lower side of gut). During extended germ band stage, expressed in ectoderm as a medial band throughout the trunk.
數據庫鏈接：

KEGG: dme:Dmel_CG8804

STRING: 7227.FBpp0087635

UniGene: Dm.3348