Recombinant Dictyostelium discoideum Sphingosine-1-phosphate lyase (sglA)

in vitro E.coli expression system

中文名稱：

盤基網柄菌sglA重組蛋白
貨號：

CSB-CF703834DKK
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

sglA
Uniprot No.：

Q54RV9
別名：

sglA; DDB_G0282819; Sphingosine-1-phosphate lyase; S1P lyase; S1PL; SP-lyase; SPL; Sphingosine-1-phosphate aldolase
種屬：

Dictyostelium discoideum (Slime mold)
蛋白長度：

full length protein
表達區域：

1-528
氨基酸序列

MDKANDYLKDYQPAKLVLATAGITAASILAYQAITDRDFKDKLNKKIFRSIKSMPGVSDI VKKERAKAKVELKKMFKTDVRNAHYTLPLKGIKHEDLIEEMKALAKVDESHWVDSKVSGC VYLGEKEHTKLLNEAYSLFSLSNPLHPSVFPSIRKFETESISMVSNMLNAHSKVVGSLTS GGTESIFMAVKAYRDFYKDRTDRPEIVVPVTIHAAFDKACEYLKIRIVHIDVDPVSYKVD MAAMKKAINKDTILVAGSAVNFPHGIIDPIDEIAKLAQQYDIGCHVDACLGGFILPFAEK LDYDIPVFDFRIPGVTSMSVDTHKFGYAAKGTSVVLFGNKKLRRAMYFVAPNWPGGIYAS PTLPGSRPGGLVAACWASLVSMGNDGFLEKAKGVMETTKKIIKGLQSINGVKIIGDPKAM VVAFTCDNIFYVNDYMSKKGWHLNALQRPNSLHVCVTAKMIGMESLFIEDLKDSIKLVKD NSGSLPKDGTAPIYGSAHSVPDREMVGTILSDFIDELITPDYKPSQST
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingosine-1-phosphate (S1P) probably acts intracellularly as a second messenger perhaps by promoting cell proliferation; the absence of S1P lyase increases its concentration. This leads to increased lateral pseudopod formation as well as defects in the efficiency of chemotaxis. Overexpression of S1P lyase causes decreased growth rates, entry into stationary phase at lower cell density and increased sensitivity to the antitumor agents cisplatin and carboplatin; these effects are more pronounced in cells that express more enzyme.
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass membrane protein.
蛋白家族：

Group II decarboxylase family, Sphingosine-1-phosphate lyase subfamily
數據庫鏈接：

KEGG: ddi:DDB_G0282819

STRING: 44689.DDB0214888