Recombinant Danio rerio Tail-anchored protein insertion receptor WRB (wrb)

in vitro E.coli expression system

中文名稱：

斑馬魚wrb重組蛋白
貨號：

CSB-CF721922DIL
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

wrb
Uniprot No.：

Q6DRM0
別名：

get1; wrb; Guided entry of tail-anchored proteins factor 1; Tail-anchored protein insertion receptor WRB; Tryptophan-rich basic protein
種屬：

Danio rerio (Zebrafish) (Brachydanio rerio)
蛋白長度：

full length protein
表達區域：

1-170
氨基酸序列

MAAGFNWFLVLSSVFLCNLVKTFLPSISSFLSKIFHKDADQEMEMRTEIQNMKMELSTIS MMDEFARYARLERKINKMTDQLKTLVKSRTAQQAKMKWIVNIAFYILQAALMISLILKYY ADPVTVVPSKWIAPLERLVAFPSGVAGGVGITCWLVVCNKVVALILQAVS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required to ensure correct topology and ER insertion of CAMLG.
基因功能參考文獻：
1. Wrb may have tissue-specific functions in the visual system and heart, or can maintain dual functions even in the same tissue. The selectivity of the defects at sensory neuron ribbon synapses suggests unique biosynthetic demands for cells bearing ribbon synapses, but may also point to a novel role for Wrb acting through the GET pathway in synaptic function. PMID: 27273592
2. WRB plays a critical role in synaptic functions in inner-ear hair cells and retinal photoreceptors. PMID: 26593130
亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

WRB/GET1 family
數據庫鏈接：

KEGG: dre:335756

STRING: 7955.ENSDARP00000100769

UniGene: Dr.86086