Recombinant Rat Neurofascin (Nfasc), partial

中文名稱：

大鼠Nfasc重組蛋白
貨號：

CSB-YP015743RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Nfasc重組蛋白
貨號：

CSB-EP015743RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Nfasc重組蛋白
貨號：

CSB-EP015743RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Nfasc重組蛋白
貨號：

CSB-BP015743RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Nfasc重組蛋白
貨號：

CSB-MP015743RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nfasc
Uniprot No.：

P97685
別名：

NfascNeurofascin
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Isoform 2/isoform 3 may be responsible for mediating and signaling axon-glial interaction during the early stages of myelination.
基因功能參考文獻：
1. Neurofascin knockdown rats also exhibited impaired learning under stress in the two-way shuttle avoidance task. PMID: 25511445
2. Spreading of the antibody response to neurofascin occurred in demyelinating experimental autoimmune encephalomyelitis PMID: 26511327
3. miR-592 may play a role in neural progenitor cell differentiation and neuronal maturation through regulating Lrrc4c and Nfasc in rat. PMID: 23971736
4. overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways. PMID: 21576239
5. The results suggest that the association of Neurofascin 155 to microdomains in the oligodendrocyte membrane is required for its participation in intermolecular interactions, which are important for myelination and/or myelin integrity. PMID: 15691718
6. A novel site of high-density sodium channel clustering in the inner plexiform layer of the retina is described, marked by neurofascin and ankyrin-G. PMID: 15797713
7. axonal neurofascin plays a critical role in clustering of Na+ channels at nodes of Ranvier via interactions with receptors on Schwann cells. PMID: 16566914
8. Neurofscin is highly diffusible in young stage 3 neurons all along the axon but becomes restricted in its diffusion in the axonal initial segments coincident with the accumulation of ankyrin G there. PMID: 17234591
9. Data show that neurofascin assembles a specialized extracellular matrix at the axon initial segment. PMID: 17709431
10. antibodies to neurofascin selectively targeted nodes of Ranvier, resulting in deposition of complement, axonal injury, and disease exacerbation PMID: 17846150
11. Results describe the differential expression and functions of neuronal and glial neurofascin isoforms and splice variants during peripheral nervous system development PMID: 17936266
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 colocalizes with ankyrin G at the nodes of Ranvier. Isoform 2/ isoform 3 is a glial component of the paranodal axo-glial junction.
蛋白家族：

Immunoglobulin superfamily, L1/neurofascin/NgCAM family
組織特異性：

Isoform 1 is expressed at Nodes of Ranvier while isoform 2/isoform 3 is expressed in unmyelinated axons.
數據庫鏈接：

KEGG: rno:116690

STRING: 10116.ENSRNOP00000057594

UniGene: Rn.3048