Recombinant Xenopus tropicalis Serine/threonine-protein kinase 4 (stk4)

中文名稱：

熱帶爪蟾stk4重組蛋白
貨號：

CSB-YP744043XBF
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

熱帶爪蟾stk4重組蛋白
貨號：

CSB-EP744043XBF
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

熱帶爪蟾stk4重組蛋白
貨號：

CSB-EP744043XBF-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

熱帶爪蟾stk4重組蛋白
貨號：

CSB-BP744043XBF
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

熱帶爪蟾stk4重組蛋白
貨號：

CSB-MP744043XBF
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

stk4
Uniprot No.：

Q6P3Q4
別名：

stk4; TTpA008i22.1; Serine/threonine-protein kinase 4; EC 2.7.11.1) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit; MST1/N); Serine/threonine-protein kinase 4 18kDa subunit; MST1/C)]
種屬：

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
蛋白長度：

full length protein
表達區域：

1-485
氨基酸序列

METVQLRNNP RRHLKKLSEE SLNKQPEEVF DVLEKLGEGS YGSVYKASHK ETSQIVAIKQ IPVESDLQEI IKEIAIMQQC DSLHVVKYYG SYFKNTDLWI VMEFCGGGSI SDIIRLRKQT LKEDETATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNSE GTAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYAEIHPM RAIFMIPSNP PPTFRKPELW SKDFVDFINL CLVKNPELRS SATELLQHPF IKTAKGESIL RHLINEAQDA KLKRTELKQR EVEPEEEENA DEDEADVGTM VQAGSKDLNT MKEFSTMNEA ADCTMVEKDK LNTQMGTMLI NDEDEEETGT MKQCTEPVQP AKPSFLEYFE QKENQFGTPE KTTPAPSTDP SEWKIPLNGD YSFLKDWSVT ELQLRLNSLD PMMEQEIEEI HHKYQAKRQP ILEAIESKKR RQQNF
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis.
基因功能參考文獻：
1. Results indicate that Mst1/2 act as a differentiation switch in hematopoietc and endothelial progenitors. PMID: 23873372
亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
數據庫鏈接：

KEGG: xtr:394860

STRING: 8364.ENSXETP00000049383

UniGene: Str.19894