Recombinant Xenopus laevis Sestrin-1 (sesn1)

中文名稱：

有爪蟾蜍sesn1重組蛋白
貨號(hào)：

CSB-YP021095XBE
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

有爪蟾蜍sesn1重組蛋白
貨號(hào)：

CSB-EP021095XBE
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

有爪蟾蜍sesn1重組蛋白
貨號(hào)：

CSB-EP021095XBE-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

有爪蟾蜍sesn1重組蛋白
貨號(hào)：

CSB-BP021095XBE
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

有爪蟾蜍sesn1重組蛋白
貨號(hào)：

CSB-MP021095XBE
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

sesn1
Uniprot No.：

P58003
別名：

sesn1; pa26; Sestrin-1; EC 1.11.1.15; XPA26; p53-regulated protein PA26
種屬：

Xenopus laevis (African clawed frog)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-481
氨基酸序列

MRLSPRAALS SPEIICSRCS QSCNNKELGI RIPRPLGQGP SRFVPEEEIL QLASEDANMH SVFADAFTDL GRLDNITLVM VFHPQYLESF LKTQHYLLQM DGPLSPCYQH YIGIMAASRH QCSYLVNLHV NDFIHHGGDQ KWLNGLENAP QKLRNLGELN KMLAHRPWLI TKEHIKQLLK AGEHSWSLAE LIHAIVLLAH YHSLASFTFG CGINPEIHSN GGHTFRPPSV SNYCICDITN GNHGTEGHLP VGIVMPTDST CEVEALMVKM KQLQEGRDEE EASQEEMATR FEREKTESMV FSTEDEDPPP DIDVSRHFED TSYGYKDFSR RGMHVPTFRV QDYSWEDHGY SLVNRLYPDV GQLLDEKFHI AYNLTYNTMA MHKDVDTSTL RRAVWNYVHC MFGIRYDDYD YGEINQLLDR SFKVYIKNVV CSPEKTSKRM YDGFWRQFKH SEKVHVNLLL MEARMQGELL YALRAITRYM T
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein.
亞細(xì)胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Sestrin family
數(shù)據(jù)庫鏈接：

KEGG: xla:379559

UniGene: Xl.12255