Recombinant Treponema pallidum 47 kDa membrane antigen (TP_0574)

中文名稱：

梅毒螺旋體TP_0574重組蛋白
貨號：

CSB-YP339039TPR
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

梅毒螺旋體TP_0574重組蛋白
貨號：

CSB-EP339039TPR
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

梅毒螺旋體TP_0574重組蛋白
貨號：

CSB-EP339039TPR-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

梅毒螺旋體TP_0574重組蛋白
貨號：

CSB-BP339039TPR
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

梅毒螺旋體TP_0574重組蛋白
貨號：

CSB-MP339039TPR
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TP_0574
Uniprot No.：

P29723
別名：

TP_0574; Putative DD-carboxypeptidase TP_0574; EC 3.4.-.-; 47 kDa lipoprotein; Tp47; Tpp47; 47 kDa membrane antigen; 47-kilodalton major integral membrane immunogen
種屬：

Treponema pallidum (strain Nichols)
蛋白長度：

Full Length of Mature Protein
表達區域：

20-434
氨基酸序列

C GSSHHETHYG YATLSYADYW AGELGQSRDV LLAGNAEADR AGDLDAGMFD AVSRATHGHG AFRQQFQYAV EVLGEKVLSK QETEDSRGRK KWEYETDPSV TKMVRASASF QDLGEDGEIK FEAVEGAVAL ADRASSFMVD SEEYKITNVK VHGMKFVPVA VPHELKGIAK EKFHFVEDSR VTENTNGLKT MLTEDSFSAR KVSSMESPHD LVVDTVGTGY HSRFGSDAEA SVMLKRADGS ELSHREFIDY VMNFNTVRYD YYGDDASYTN LMASYGTKHS ADSWWKTGRV PRISCGINYG FDRFKGSGPG YYRLTLIANG YRDVVADVRF LPKYEGNIDI GLKGKVLTIG GADAETLMDA AVDVFADGQP KLVSDQAVSL GQNVLSADFT PGTEYTVEVR FKEFGSVRAK VVAQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus. Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates. May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete. Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, not the lipoprotein moiety, is toxic. Binds penicillin. Penicillin binding is covalent, does not require lipidation, and is zinc-dependent. While this protein has beta-lactamase activity in vitro, that is probably not its role in vivo, as T.pallidum is very sensitive to penicillin antibiotics.; A pathogen-specific membrane antigen. Most abundant of the membrane lipoproteins, only found in pathogenic treponemes, suggesting that it is an important structural moiety in the cell envelope of virulent treponemal subspecies. A lipopeptide corresponding to the first 6 mature residues induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells. Stimulates host (human) dendritic cell maturation to become MHC class II-positive antigen presenting cells via TLR2, which depends on lipidation; nonlipidated protein does not stimulate maturation.
亞細胞定位：

Cell inner membrane; Lipid-anchor.
數據庫鏈接：

KEGG: tpa:TP_0574

STRING: 243276.TP0574