Recombinant Structure-specific endonuclease subunit SLX1 homolog (giyd-1)
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中文名稱：秀麗隱桿線蟲slx-1重組蛋白
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貨號：CSB-EP309347CXY-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：slx-1
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Uniprot No.：
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別名：slx-1; giyd-1; F56A3.2; Structure-specific endonuclease subunit SLX1 homolog; EC 3.1.-.-; GIY-YIG domain-containing protein 1
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種屬：Caenorhabditis elegans
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蛋白長度：full length protein
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表達區域：1-443
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氨基酸序列METFILSSDS DDDSGPPPSK RRTIEGIPRS FSGDKKIRFS FGASNMSQDT TQEIIPEDTD TVPLTIPSTP ALSGKFDSKT PKSVRRRSVS MSCFTPIVET INQPPTNQAC SSFLQKEYNF HDLSSDEEGG DGGAGCSKDE DKIIEDNLNL RALLSPEKKK RKEKIEEVQN EFYGVYCLIS RSDRPCYKNR CYIGYTVDPN RRIMQHNGGR DKGGAKKTDS RGPWDMVCVV HGFPNHVAAL HFEWAWQNPL VSKSLKEKQL RKERKETPFA FQLRIACELM NSSAFCRFAL TFRWLITTEE LPFPTSCVPP DHTKLRFGKV KKEMSLVPSK REDYLEMGEC RICGKDIEKL WSLVRCISAT CPSHFHSKCL SENGLKLKNE HVDHVYPLKA NCPTCGQFYL WGDIIREQRR IIKISTKCAE EFQNMVVRKE LPHREISPIS SKK
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
靶點詳情
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功能：Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the central region of chromosomes.
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基因功能參考文獻：
- SLX-1 shows a HIM-18/SLX-4-dependent endonuclease activity toward replication forks, 5'-flaps, and Holliday junctions. slx-1 mutants exhibit hypersensitivity to UV, nitrogen mustard, and camptothecin, but not gamma irradiation. PMID: 22927825
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亞細胞定位：Nucleus.
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蛋白家族：SLX1 family
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數據庫鏈接：
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