Recombinant Streptococcus pyogenes serotype M1 Streptopain (speB)

中文名稱：

Recombinant Streptococcus pyogenes serotype M1 Streptopain(speB)
貨號：

CSB-YP313469SMT
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Streptococcus pyogenes serotype M1 Streptopain(speB)
貨號：

CSB-EP313469SMT
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Streptococcus pyogenes serotype M1 Streptopain(speB)
貨號：

CSB-EP313469SMT-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Streptococcus pyogenes serotype M1 Streptopain(speB)
貨號：

CSB-BP313469SMT
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Streptococcus pyogenes serotype M1 Streptopain(speB)
貨號：

CSB-MP313469SMT
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

speB
Uniprot No.：

P0C0J1
別名：

speB; SPy_2039; M5005_Spy1735; Streptopain; EC 3.4.22.10; Exotoxin type B; SPE B; Streptococcal cysteine proteinase; Streptococcus peptidase A; SPP
種屬：

Streptococcus pyogenes serotype M1
蛋白長度：

Full Length of Mature Protein
表達區域：

146-398
氨基酸序列

QPVVK SLLDSKGIHY NQGNPYNLLT PVIEKVKPGE QSFVGQHAAT GCVATATAQI MKYHNYPNKG LKDYTYTLSS NNPYFNHPKN LFAAISTRQY NWNNILPTYS GRESNVQKMA ISELMADVGI SVDMDYGPSS GSAGSSRVQR ALKENFGYNQ SVHQINRGDF SKQDWEAQID KELSQNQPVY YQGVGKVGGH AFVIDGADGR NFYHVNWGWG GVSDGFFRLD ALNPSALGTG GGAGGFNGYQ SAVVGIKP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.
基因功能參考文獻：
1. The great majority of group A streptococcus strains recovered from infected humans secrete wild-type levels of SpeB protease activity. PMID: 26416912
2. SpeB is the proteolytic factor that cleaves E-cadherin in the region neighboring the calcium-binding sites within the extracellular domain. PMID: 23532847
3. Srv regulated control of SpeB may mediate biofilm formation and dispersal in diverse strain backgrounds PMID: 22163320
4. propose that the human plasminogen system plays a critical role in group A streptococcal M1T1 systemic disease initiation. SpeB is required for S. pyogenes M1T1 survival at the site of local infection PMID: 16790522
5. The proteolytic effect of SpeB on 5 S. pyogenes superantigens is reported; only SpeZ was completely degraded by the enzyme. PMID: 16980693
6. amino acid requirements for IgG glycan-hydrolyzing activity of EndoS; findings show cysteine proteinase SpeB processes/degrades EndoS & emphasizes importance of SpeB as a degrading/processing enzyme of proteins from the bacterium itself PMID: 18182097
7. data show that an intact RopB and efficient SpeB production are necessary for systemic infection with group A Streptococcus PMID: 19116661
8. SpeB destroys most of the signaling and antibacterial properties of chemokines expressed by an inflamed epithelium. PMID: 19274094
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亞細胞定位：

Secreted.
蛋白家族：

Peptidase C10 family
數據庫鏈接：

KEGG: spy:SPy_2039

STRING: 160490.SPy_2039