Recombinant Sheep Corticosteroid 11-beta-dehydrogenase isozyme 1 (HSD11B1), partial

中文名稱：

綿羊HSD11B1重組蛋白
貨號：

CSB-YP010763SH1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

綿羊HSD11B1重組蛋白
貨號：

CSB-EP010763SH1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

綿羊HSD11B1重組蛋白
貨號：

CSB-EP010763SH1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

綿羊HSD11B1重組蛋白
貨號：

CSB-BP010763SH1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

綿羊HSD11B1重組蛋白
貨號：

CSB-MP010763SH1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HSD11B1
Uniprot No.：

P51975
別名：

HSD11B1; Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1
種屬：

Ovis aries (Sheep)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
基因功能參考文獻：
1. These results support the idea that the effects of HSD11B1-derived cortisol on conceptus elongation are indirectly mediated by the endometrium and are not directly mediated through GR in the trophectoderm PMID: 26085523
2. Studies support the idea that IFNT and PGs from the conceptus regulate endometrial HSD11B1 expression and activity that regenerates bioactive cortisol in the ovine uterus during early pregnancy to influence endometrial functions and conceptus elongation. PMID: 22205698
3. Endometrial epithelial HSD11B1 expression is induced by progesterone as well as stimulated by interferon tau and PTGS2-derived prostaglandins. PMID: 19696010
4. hepatic expression of 11beta-hydroxysteroid dehydrogenase type 1 increased in placental restriction-hypoxic reduced liver growth PMID: 19208549
亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type II membrane protein.
蛋白家族：

Short-chain dehydrogenases/reductases (SDR) family
組織特異性：

Liver, kidney, lung, hypothalamus, anterior pituitary and placenta.
數據庫鏈接：

KEGG: oas:443409

UniGene: Oar.418