Recombinant Schizosaccharomyces pombe Serine/threonine-protein kinase ark1 (ark1)

中文名稱：

Recombinant Schizosaccharomyces pombe Serine/threonine-protein kinase ark1(ark1)
貨號(hào)：

CSB-YP528879SXV
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Schizosaccharomyces pombe Serine/threonine-protein kinase ark1(ark1)
貨號(hào)：

CSB-EP528879SXV
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Schizosaccharomyces pombe Serine/threonine-protein kinase ark1(ark1)
貨號(hào)：

CSB-EP528879SXV-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Schizosaccharomyces pombe Serine/threonine-protein kinase ark1(ark1)
貨號(hào)：

CSB-BP528879SXV
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Schizosaccharomyces pombe Serine/threonine-protein kinase ark1(ark1)
貨號(hào)：

CSB-MP528879SXV
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

ark1
Uniprot No.：

O59790
別名：

ark1; sex1; SPCC320.13c; SPCC330.16Serine/threonine-protein kinase ark1; EC 2.7.11.1; Aurora-related kinase 1
種屬：

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-355
氨基酸序列

MSDSKLADSL NCLSVSTPST TANPGRQQLL RLAVSNQRQV NNVSLANGKE NKRTSNSKFN SSLRKIEEPI AGVPSSAGPQ WREFHIGMFE IGKPLGKGKF GRVYLAKEKK TGFIVALKTL HKSELVQSKI EKQVRREIEI QSNLRHKNIL RLYGHFHDEK RIYLILEFAG RGELYQHLRR AKRFSEEVAS KYIFQMANAL SYLHKKHVIH RDIKPENILL GIDGEIKLSD FGWSVHAPSN RRTTLCGTLD YLPPEMVEGK EHTEKVDLWS LGVLTYEFLV GAPPFEDMSG HSATYKRIAK VDLKIPSFVP PDARDLISRL LQHNPEKRMS LEQVMRHPWI VKYKDSWTRK SSESS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis.
基因功能參考文獻(xiàn)：
1. A new role for Aurora B in telomere dispersion and disjunction during fission yeast mitosis. PMID: 25778919
2. promotes cell division during recovery from TOR-mediated cell cycle arrest by driving spindle pole body recruitment of Polo PMID: 21965528
3. genetic and cytological analyses suggest that the interplay of chiasmata and kinetochore geometry leads to correct silencing of Aurora B activity at centromeres, providing insight into how chiasmata regulate meiotic chromosome orientation. PMID: 21920317
4. the Cnd2 subunit of condensin is the target subunit of Aurora-B-like kinase Ark1 and that Ark1-mediated phosphorylation of Cnd2 occurred throughout mitosis PMID: 21540296
亞細(xì)胞定位：

Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Associates with the elongating spindle during anaphase.
蛋白家族：

Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
數(shù)據(jù)庫鏈接：

KEGG: spo:SPCC320.13c

STRING: 4896.SPCC320.13c.1