Recombinant Schizosaccharomyces pombe Polyadenylate-binding protein 2 (pab2)

中文名稱：

龐貝裂殖酵母pab2重組蛋白
貨號：

CSB-YP017365SXV
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

龐貝裂殖酵母pab2重組蛋白
貨號：

CSB-EP017365SXV
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

龐貝裂殖酵母pab2重組蛋白
貨號：

CSB-EP017365SXV-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

龐貝裂殖酵母pab2重組蛋白
貨號：

CSB-BP017365SXV
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

龐貝裂殖酵母pab2重組蛋白
貨號：

CSB-MP017365SXV
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

pab2
Uniprot No.：

O14327
別名：

pab2; SPBC16E9.12c; Polyadenylate-binding protein 2; PABP-2; Poly(A)-binding protein 2; Poly(A)-binding protein II; PABII
種屬：

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
蛋白長度：

full length protein
表達區域：

1-166
氨基酸序列

MSDQDALDTQ EKELLEMKER VAEMEAEAAK LRAMQEQLDN ETEALRNDKE SIDAQSVYVG NVDYSVTPEE LQSHFASCGS VNRVTILCDK FTGHPKGFAY IEFSEPSLVP NALLLNGSML HERPLKVTPK RTNVPGMSRG RGRGRGRGRG RGRGGYRGRA RGFAPY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. Whereas PABPN1 strongly increases the activity of its cognate poly(A) polymerase in vitro, Pab2 was unable to stimulate Pla1 to any significant extent. PMID: 28096519
2. Pab2 functions with Rrp6 to negatively control Tf2 mRNA accumulation. the absence of Pab2 attenuated the derepression of Tf2 transcription and the increased frequency of Tf2 mobilization caused by the deletion of abp1. PMID: 28007890
3. Nab2 impedes Pab2/Rrp6-mediated decay by competing with Pab2 for polyadenylated transcripts in the nucleus. PMID: 24081329
4. A proline-tyrosine nuclear localization signal is necessary and sufficient for nuclear import of Pab2. PMID: 23279110
5. Pab2 and the nuclear exosome subunit, Rrp6 are the main factors involved in this polyadenylation-dependent pre-mRNA degradation pathway PMID: 21981922
6. a model in which Mmi1 selectively targets meiotic transcripts for degradation via Pab2 and the exosome PMID: 20622014
7. Pab2 promotes poly(A) tail trimming from pre-snoRNAs by recruiting the nuclear exosome. PMID: 20129053
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亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: spo:SPBC16E9.12c

STRING: 4896.SPBC16E9.12c.1