Recombinant Schizosaccharomyces pombe Phosphatidylinositol 3-kinase tor1 (tor1), partial

中文名稱：

龐貝裂殖酵母tor1重組蛋白
貨號：

CSB-YP521136SXV
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

龐貝裂殖酵母tor1重組蛋白
貨號：

CSB-EP521136SXV
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

龐貝裂殖酵母tor1重組蛋白
貨號：

CSB-EP521136SXV-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

龐貝裂殖酵母tor1重組蛋白
貨號：

CSB-BP521136SXV
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

龐貝裂殖酵母tor1重組蛋白
貨號：

CSB-MP521136SXV
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

tor1
Uniprot No.：

O14356
別名：

tor1; SPBC30D10.10c; Serine/threonine-protein kinase tor1; EC 2.7.11.1; Phosphatidylinositol kinase homolog tor1; Target of rapamycin kinase 1
種屬：

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Phosphatidylinositol 3-kinase homolog, component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Responsible for the phosphorylation of AGC kinase gad8 at 'Ser-527' and 'Ser-546', activating gad8 kinase activity and promoting sexual development.
基因功能參考文獻：
1. While mutated TORC1 and TORC2 displayed diminished kinase activity and FKBP12/Fkh1-dependent rapamycin sensitivity, their phenotypes were nearly opposite in mitosis. PMID: 22645648
2. Tor1 and the Tsc1-2 complex work in parallel positively regulating amino acid uptake through the control of expression of amino acid permeases, and either one is required for growth on a poor nitrogen source. PMID: 17179073
3. Results suggest that S. pombe Tor1 and Tor2 can both act in TORC1, but it is the inhibition of Tor1 as part of TORC1 that promotes mitosis following nutrient stress. PMID: 19417002
4. Data highlight critical roles for TORC2 and its component Tor1 in chromatin metabolism and in promoting mitotic entry, most notably after recovery from DNA-damaging conditions. PMID: 19546237
亞細胞定位：

Cytoplasm.
蛋白家族：

PI3/PI4-kinase family
數據庫鏈接：

KEGG: spo:SPBC30D10.10c

STRING: 4896.SPBC30D10.10c.1