Recombinant Rat Vimentin (Vim)

中文名稱：

大鼠Vim重組蛋白
貨號：

CSB-YP025857RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Vim重組蛋白
貨號：

CSB-EP025857RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Vim重組蛋白
貨號：

CSB-EP025857RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Vim重組蛋白
貨號：

CSB-BP025857RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Vim重組蛋白
貨號：

CSB-MP025857RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Vim
Uniprot No.：

P31000
別名：

Vim; Vimentin
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-466
氨基酸序列

STRSVSSSS YRRMFGGSGT SSRPSSNRSY VTTSTRTYSL GSALRPSTSR SLYSSSPGGA YVTRSSAVRL RSSMPGVRLL QDSVDFSLAD AINTEFKNTR TNEKVELQEL NDRFANYIDK VRFLEQQNKI LLAELEQLKG QGKSRLGDLY EEEMRELRRQ VDQLTNDKAR VEVERDNLAE DIMRLREKLQ EEMLQREEAE STLQSFRQDV DNASLARLDL ERKVESLQEE IAFLKKLHDE EIQELQAQIQ EQHVQIDVDV SKPDLTAALR DVRQQYESVA AKNLQEAEEW YKSKFADLSE AANRNNDALR QAKQESNEYR RQVQSLTCEV DALKGTNESL ERQMREMEEN FALEAANYQD TIGRLQDEIQ NMKEEMARHL REYQDLLNVK MALDIEIATY RKLLEGEESR ISLPLPNFSS LNLRETNLES LPLVDTHSKR TLLIKTVETR DGQVINETSQ HHDDLE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
基因功能參考文獻：
1. We labeled brain with ZO1, vimentin, pan-cadherin and angiotensin II type 1 receptors markers which showed a morphologically distinct population of cells at the region of the sulcus medianus organum similar to tanycytes present in the median eminence, a known circumventricular organ. PMID: 29803674
2. In transected spinal cord rats, vimentin knockdown in the scar tissues showed a significant improvement on locomotor function in hindlimbs. PMID: 24874717
3. The increased expression of LP-vimentin-IR cells suggests that changes in cell-cell interactions could play a role in ischemia-induced changes in bladder activity. PMID: 24728265
4. Double-immunostaining experiments with antibodies against Stk33 and vimentin showed a striking colocalization of Stk33 and vimentin in the hypothalamus. PMID: 24057876
5. We have identified three protein biomarkers (GSN, MYL2, and VIM) that have potential utility in diagnosing the severity of Chagas disease PMID: 22199233
6. vimentin is a regulator of NRG1 type III function and peripheral nerve myelination PMID: 22357929
7. Estradiol treatment leads to an effect on vimentin phosphorylation. PMID: 21915674
8. These data suggest that the inability of YY1 to access the hypermethylated promoter may be one of the mechanisms that mediate vimentin downregulation. PMID: 22005459
9. Data show that vimentin intermediate filaments play a crucial role in mechanical behavior not only at large deformations but also in the nanomechanical response of individual cells. PMID: 21426942
10. Data show that astrocyte structural proteins GFAP and vimentin are induced and by chronic leptin administration, suggesting astrocytes participating in leptin modulated synaptic inputs. PMID: 21343257
11. GR-mediated reduction in vimentin may be involved in the formation of steroid-induced cataract PMID: 21245955
12. Increases in post-traumatic vimentin mRNA in the cortex and in the hippocampus appear together with vimentin immunoreactivity in astrocytes starting at one day after severe trauma. PMID: 20479526
13. Endothelial cell hypoxia causes redistribution of vimentin to a more insoluble and extensive filamentous network that could play a role in endothelial barrier stabilization. PMID: 20427712
14. Vimentin mRNA and protein expression levels increased significantly throughout hepatotumorigenesis. Vimentin is an important node in underlying gene regulatory networks. PMID: 20015863
15. Fetal hepatocytes at the epithelial mesenchymal transition have a higher level of this protein than in fetal hepatocytes. PMID: 12496370
16. induction in glial cells of hippocampus following hyperthermia PMID: 12834255
17. vimentin may play a key role in the formation of glial scars in the central nervous system PMID: 15684657
18. demonstrate the alterations of alpha-smooth muscle actin and vimentin localization patterns in the bovine cryptorchid testis as compared to the contralateral scrotal testis during postnatal development PMID: 16493181
19. Taken together, these results suggest that vimentin is a novel member of binding partner of PP1c in astrocytes, and vimentin-Ser82 may act as a memory phosphorylation site. PMID: 16629905
20. Vimentin phosphorylation was increased, indicating an accumulation of phosphorylated vimentin associated to the cytoskeleton in hyperthyroidism induced rats. PMID: 17306450
21. Rats fed the homocysteine diet had an increase in Vim. PMID: 17485853
22. vimentin-immunopositive cells localize (in both intact and lesioned brain) in the zone of barrier structures' formation. PMID: 18198667
23. the phosphorylation and the immunoreactivity of cytoskeletal-associated vimentin were increased without altering vimentin expression, suggesting an accumulation of insoluble and phosphorylated vimentin. PMID: 18316471
24. Single impact load also causes changes in the pattern of vimentin immunoreactivity, indicating vimentin dissassembley in cartilage injury model PMID: 18577232
25. Vimentin was expressed in cells of the outer and inner capsules of all muscle spindles and in newly formed myoblasts and myotubes of regenerating spindles 7 days after grafting PMID: 18941770
26. Vimentin was observed within cells located in the primitive ducts of rat pancreas newborn animals. It was also spotted in alpha cells starting from E12.5 but disappeared soon after birth, likely identifying immature or recently differentiated alpha cells. PMID: 19223297
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亞細胞定位：

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus matrix. Cell membrane.
蛋白家族：

Intermediate filament family
數據庫鏈接：

KEGG: rno:81818

STRING: 10116.ENSRNOP00000024430

UniGene: Rn.2710