Recombinant Rat Sterol regulatory element-binding protein 1 (Srebf1), partial
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中文名稱：大鼠Srebf1重組蛋白
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貨號：CSB-EP022657RA1-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：Srebf1; Srebp1; Sterol regulatory element-binding protein 1; SREBP-1; Adipocyte determination- and differentiation-dependent factor 1; ADD1; Sterol regulatory element-binding transcription factor 1
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種屬：Rattus norvegicus (Rat)
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蛋白長度：partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
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靶點詳情
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功能：Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis.; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation.; Isoform expressed only in select tissues, which has higher transcriptional activity compared to SREBP-1C. Able to stimulate both lipogenic and cholesterogenic gene expression. Has a role in the nutritional regulation of fatty acids and triglycerides in lipogenic organs such as the liver. Required for innate immune response in macrophages by regulating lipid metabolism.; Predominant isoform expressed in most tissues, which has weaker transcriptional activity compared to isoform SREBP-1A. Primarily controls expression of lipogenic gene. Strongly activates global lipid synthesis in rapidly growing cells.
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基因功能參考文獻：
- SREBP1c and SREBP2 are transcriptional regulators of the thyroglobulin gene in thyroid cells. PMID: 27321819
- PPAR-alpha inhibitor (Blueberry Juice and Probiotics) increased the level of SREBP-1c and PNPLA-3 and prevents nonalcoholic steatohepatitis progression by affecting SREBP-1c/PNPLA-3 pathway via PPAR-alpha. PMID: 28264426
- The involvement of SREBP-1c in FASN promoter histone modification. PMID: 28027934
- GSK-3-mediated phosphorylation of serine 73 in the rat SREBP-1c and its concomitant destabilization represents a novel mechanism involved in the inhibition of de novo lipid synthesis in the liver. PMID: 26589965
- Betahistine could act on hepatic H1 receptors via modulation of AMPKalpha-SREBP-1. PMID: 26218603
- a novel regulatory mechanism by which n-3 PUFA inhibit induction of SREBP-1c by insulin. PMID: 26327595
- Gene expression studies show Srebf-1c was increased in the mammary gland, liver and adipose tissue of rats fed a low-lipid diet compared with rats from the adequate-lipid diet group throughout pregnancy and lactation. PMID: 25046614
- The V-shaped chronological alterations in white adipose tissue (WAT) are regulated via SREBP1c, which is probably activated by CR duration-dependent modulation of both insulin and leptin signaling. PMID: 25616173
- Angiotensin II-induced activation of SREBP-1 required signaling through the angiotensin II type I receptor and activation of PI3K/Akt in addition to the chaperone SCAP and protease S1P. PMID: 25398788
- SREBP-1c activation participates in skeletal muscle insulin resistance through a direct effect of suppressing Irs-1 transcription. PMID: 24362725
- Maternal fructose intake during pregnancy causes maternal hyperglycemia and up-regulates hepatic SREBP-1c expression in both fetuses and dams. PMID: 23065593
- Raising plasma insulin to postprandial levels, increased SREBP-1 mRNA comparably in livers and epidydimal adipose tissue of alert, free moving rats and in adipose tissue of human subjects. PMID: 23913732
- We demonstrated that H2O2-increase in SREBP-1 protein content was due to enhancement of SREBP-1a mRNA translation. PMID: 23583293
- SREBPs are novel transcriptional regulators of NIS. PMID: 23542164
- Treatment of diabetic rats with curcumin increased the phosphorylation of AMPK and prevented the increased renal expression of SREBP-1c. PMID: 22898567
- CR-associated remodeling of WAT, which involves SREBP-1-mediated transcriptional activation and suppression of macrophage infiltration, is regulated in a GH-IGF-1-independent manner. PMID: 22645024
- the effect of leptin-induced Stat3 pathway on SREBP-1c expression in HSCs might contribute to the role of leptin in liver fibrosis in mouse, thus advancing understanding of the mechanisms of liver fibrogenesis associated with leptin. PMID: 23295202
- Our results indicate that exendin-4 inhibits the activation of SREBP1c and C/EBPbeta, which, in turn, may reduce glucolipotoxicity-induced ER stress and beta-cell apoptosis. PMID: 23257266
- The elevated hepatic expression of Raldh1 in Zucker fatty (obese) rats may cause the excessive retinoic acid production from retinol, and in turn, result in higher Srebp-1c expression. PMID: 23028851
- FoxO1 inhibits SREBP-1c transcription via combined actions on multiple transcription factors and that this effect is exerted at least in part through reduced transcriptional activity of Sp1 and SREBP-1c PMID: 22511764
- Data reveal that aberrant activation of LXR reproduced the phenomenon of beta cell dysfunction in the development of type 2 diabetes. Upregulation of SREBP1c production and the lipotoxicity mediated by it played a central role in this process. PMID: 22415588
- EGR1 upregulation paralleled the expression and transcriptional activity of SREBP1c in long-term ethanol-fed Long-Evans rats. PMID: 22292946
- SREBP1 expression was elevated in type 2 diabetic rats. Early insulin therapy reduced SREBP1 expression. PMID: 22093779
- Data show that orotic acid induces hepatic lipogenesis, mediated predominantly by the AMPK/SREBP-1 pathway in rat hepatocytes and human hepatoma cell lines. PMID: 21757781
- High sterol regulatory element binding protein-1c is associated with the pathogenesis of non-alcoholic steatohepatitis. PMID: 21986124
- The mRNA levels of one insulin-induced (Srebp-1c) and one insulin-suppressed (Pck1) genes in response to insulin, glucagon, and compactin treatments in hepatocytes were analyzed. PMID: 21731709
- The expression of GLUT4 in response to insulin and fasting/refeeding in adipose tissue and the role of sterol regulatory binding protein-1c (SREBP-1c) in GLUT4 regulation are reported. PMID: 16787385
- Orotic acid caused fatty infiltration by stimulating TG synthesis through the upregulation of SREBP-1c and its target gene involved in fatty acid biosynthesis. PMID: 21167679
- SREBP-1c and Wnt10b display inverse expression patterns during muscle ontogenesis and regeneration, as well as during satellite cells differentiation.[SREBP-1c] PMID: 20041157
- Increased expression of SREBP-1 was further observed in the liver tissues of aging Fischer 344 rats. PMID: 20615871
- The oxidative stress and nonalcoholic fatty liver disease via SREBP-1c. PMID: 19616615
- role in regulating renal lipid metabolism and glomerulosclerosis in diabetes mellitus (SREBP-1) PMID: 11875060
- plays a role in the induction of lipogenic enzyme genes in response to insulin treatment PMID: 12016216
- results suggest that the IRS-1-PI 3-kinase pathway is essential for insulin-induced expression of SREBP-1c and glucokinase genes. PMID: 12031952
- SREBP-1c expression is sensitive to insulin and can transduce the positive and negative actions of the hormone on specific genes and thus has a pivotal role in long-term muscle insulin sensitivity. PMID: 12031958
- data indicate that PUFA suppress the in vivo proteolytic release of sterol regulatory element binding proteins-1 and -2, but the effect on SREBP-2 is transitory PMID: 12421847
- sterol regulatory element binding protein-1c maturation could be implicated in the pathogenesis of beta-cell glucolipotoxicity PMID: 12600983
- study provides evidence that acetyl-CoA carboxylase beta expression in liver is regulated at the transcriptional level by the direct interaction of sterol regulatory element binding protein-1 with promoter II PMID: 12764144
- SREBP-1c RNA and SREBP-1 protein levels respond to nutritional status in skeletal muscle. PMID: 12771318
- SREBP1c has a role in regulating lipogenic enzymes and transport proteins stimulated by keratinocyte growth factor in type II alveolar cells PMID: 12865412
- Results describe the temporal relationships and role of CCAAT/enhancing-binding protein alpha, sterol regulatory element binding protein-1c, and stearoyl-CoA desaturase 1 in lipogenesis in fetal rat lung. PMID: 12896875
- sterol regulatory element-binding protein-1 gene expression has a role in hepatic lipogenesis with Protein-tyrosine phosphatase 1B PMID: 12941932
- Protein kinase B has a role in insulin-dependent induction of sterol regulatory element-binding protein 1 mRNA in hepatocytes PMID: 14505487
- Sterol regulatory element-binding protein 1 (SREBR-1) plays a role in increase of the lipogenic potential of adipose tissue after repeated dieting. PMID: 14668913
- SREBP-1c is not altered when a modest hepatic overexpression of glucokinase alters expression of metabolic genes PMID: 14674713
- SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver PMID: 14744869
- Rats fed soy protein had an elevated hepatic SREBP1 mRNA level and avoided the developomenet of fatty liver. PMID: 14988441
- skeletal muscle SREBP-1c gene expression is regulated by nutritional status in a fashion similar to that observed in liver and adipose tissue PMID: 15001432
- ADD1/SREBP1c controls adiponectin gene expression in differentiated adipocytes PMID: 15037635
- SREBP-1c is stimulated by glucose through a Jak/STAT dependent pathway and has a role in intramuscular lipid accumulation associated with muscle insulin resistance PMID: 15039461
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亞細胞定位：[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.; [Processed sterol regulatory element-binding protein 1]: Nucleus.
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蛋白家族：SREBP family
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組織特異性：Expressed predominantly in brown adipose tissue.
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