Recombinant Rat Solute carrier family 22 member 6 (Slc22a6), partial

中文名稱：

大鼠Slc22a6重組蛋白
貨號：

CSB-YP021461RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Slc22a6重組蛋白
貨號：

CSB-EP021461RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Slc22a6重組蛋白
貨號：

CSB-EP021461RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Slc22a6重組蛋白
貨號：

CSB-BP021461RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Slc22a6重組蛋白
貨號：

CSB-MP021461RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc22a6
Uniprot No.：

O35956
別名：

Slc22a6; Oat1; Solute carrier family 22 member 6; Organic anion transporter 1; rOAT1; renal organic anion transporter 1; rROAT1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD) and edaravone sulfate. Mediates the sodium-independent uptake of p-aminohippurate (PAH), cidofovir, adefovir, 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF). PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid, benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, phenol red, urate and alpha-ketoglutarate. PAH uptake is inhibited by glutarate and probenecid.
基因功能參考文獻：
1. These results indicated that OAT1 and OAT3 played crucial roles: (1) in determining baseline levels of blood BP by excluding endogenous BP through the urine, (2) in the rapid distribution to organs of exogenous BH4 and the exclusion to urine of a BH4 excess, particularly when BH4 was administered, and (3) in scavenging blood BH2 by cellular uptake as the gateway to the salvage pathway of BH4, which reduces BH2 back to BH4 PMID: 28534121
2. Furosemide pretreatment causes a decrease of p-aminohippurate renal elimination in rats in spite of the increased expression level of Oat1. PMID: 27282888
3. folic acid was capable of preventing monosodium urate-induced OAT1 relocation by inhibiting the RhoA signaling pathway. PMID: 26846716
4. In uremia, urea accounts, at least in part, for the decreased expression of Oat1 and Oat3 in proximal tubule plasma membranes. PMID: 26065488
5. Suggest that 1,25(OH)2 D3 treatment reduces cefdinir and cefadroxil clearances by diminution of renal OAT1/OAT3 expression. PMID: 25266751
6. the beneficial effect of low-dose indomethacin in ischemic acute kidney injury is not due to its anti-inflammatory potency, but in contrast to its restoration of Oat1/3 expression and/or general renal function PMID: 25391897
7. transport of xanthurenic acid by OAT1 and OAT3 PMID: 23832370
8. Hnf4alpha occupies Oat1, Oat3, and Oct1 proximal promoters in the in vivo differentiating rat kidney. PMID: 22808265
9. This paper evelautes the renal expression and function of Oat1 and Oat3 in rats with vascular calcification PMID: 22759781
10. In olfactory epithelium, high levels of expression of xenobiotic transporters Mrp1, Mrp3, Mrp5, Mdr1a, Oatp2 and Oat6 are expressed. PMID: 22015764
11. acute kidney injury by HgCl(2) was found to be mediated mainly by Oat1. PMID: 21652719
12. Triiodothyronine and dexamethasone pre-treatment induces the expression of OAT1 in kidneys of rats. PMID: 12877347
13. Localization of OAT1 in outer zona fasciculata, supporting possible role of OAT1 in cortisol release. Zonated distribution of transporters furthermore suggest that oatp1-3 and OCT2 may be important for the endocrine function of rat adrenocortical cells. PMID: 12960058
14. rOat1/hOAT1 and rOat3/hOAT3 play major roles in the renal uptake of uremic toxins on the basolateral membrane of the proximal tubules. PMID: 14675047
15. obstructive cholestasis down-regulates Oct1 and impairs Oct1-mediated uptake in rat liver, suggesting that hepatic uptake of small cationic drugs may be impaired in cholestatic liver injury. PMID: 15122767
16. bilateral ureteral obstruction was associated with down-regulation of OAT1 and OAT3 in basolateral plasma membranes from proximal tubule cells PMID: 16316345
17. key role of OAT1 expression in the impaired elimination of p-aminohippurate after 3 days of obstructive cholestasis. PMID: 16844357
18. May have substantial impact on excretion kinetics and half-life of organic anions. As a consequence, biological effects of variety of organic anions may be affected after ischemic acute renal failure. PMID: 17244891
19. Our results suggest that the downregulation of renal rOAT1 and rOAT3 could be responsible for the increase in serum indoxyl sulfate level of ischemic rats. PMID: 17245393
20. COX-2 derived prostanoids downregulate OAT1 and OAT3 during lipopolysaccharide-induced acute renal injury. PMID: 18946499
21. This study provides evidence regarding the importance of adjusting the dose regimens of negatively charged drugs during the different time phases of this pathology. PMID: 18953184
22. OAT1 appears to be one of the major contributors to renal basolateral uptake of citrulline, and impaired activities of these transporters may contribute substantially to the increase in plasma citrulline in renal failure. PMID: 19403644
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
組織特異性：

Highly expressed in kidney; in the particular segment of the proximal tubule and to a lower extent in brain. Found preferentially in the cortex and outer medulla and weakly in the inner medulla.
數據庫鏈接：

KEGG: rno:29509

STRING: 10116.ENSRNOP00000024756

UniGene: Rn.87849