Recombinant Rat Sodium channel protein type 3 subunit alpha (Scn3a), partial

中文名稱：

大鼠Scn3a重組蛋白
貨號：

CSB-YP020839RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Scn3a重組蛋白
貨號：

CSB-EP020839RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Scn3a重組蛋白
貨號：

CSB-EP020839RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Scn3a重組蛋白
貨號：

CSB-BP020839RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Scn3a重組蛋白
貨號：

CSB-MP020839RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Scn3a
Uniprot No.：

P08104
別名：

Scn3a; Sodium channel protein type 3 subunit alpha; Sodium channel protein brain III subunit alpha; Sodium channel protein type III subunit alpha; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.3
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells. In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion.
基因功能參考文獻：
1. EA attenuates SCI-induced Nav1.3 and Bax upregulation in injured spinal cord via upregulating miR-214. PMID: 28298073
2. We used a validated recombinant adeno-associated virus (AAV)-shRNA-Nav1.3 vector to knockdown expression of Nav1.3, via a clinically applicable intrathecal injection method. PMID: 26101954
3. Nav1.3 channels are involved in muscle contraction in vascular smooth muscle cells and expressed in vascular myocytes. PMID: 23364266
4. Significant upregulation in expression of Nav1.3 mRNA and protein is observed in the rat ipsilateral-injured cortex at very early stage post-traumatic brain injury (TBI), correlating with TBI severity. PMID: 22928478
5. injury to ventral root might lead to neuropathic pain and the re-expression of Nav1.3 in primary sensory neurons by activation of NF-kappaB PMID: 20858468
6. Data provide a pathophysiological basis for the pathogenicity of the first epilepsy-linked mutation within Na(V)1.3 channels and hippocampal neurons. PMID: 20420834
7. Upregulation of Nav1.3 in dorsal horn nociceptive neurons after experimental spinal cord injury was noted suggesting a functional link between Nav1.3 expression and neuronal hyperexcitability associated with central neuropathic pain PMID: 14523090
8. results show changed sodium channel expression in higher-order spinal sensory neurons after peripheral nerve injury and suggest a link between misexpression of Na(v)1.3 sodium channels and central mechanisms of neuropathic pain after injury. PMID: 15152043
9. Na(V)1.3 labeling was present in nerve fibers and cell bodies (but not myocytes) and was abundant in the penetrating atrioventricular (AV) bundle and the common bundle but was much less abundant in other regions. PMID: 16966585
10. This observation of a potentially pathogenic mutation of SCN3A (Nav1.3) indicates that this gene should be further evaluated for its contribution to childhood epilepsy. PMID: 18242854
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Sodium channel (TC 1.A.1.10) family, Nav1.3/SCN3A subfamily
數據庫鏈接：

KEGG: rno:497770

STRING: 10116.ENSRNOP00000006646

UniGene: Rn.87394