Recombinant Rat Sodium channel protein type 1 subunit alpha (Scn1a), partial

中文名稱：

大鼠Scn1a重組蛋白
貨號：

CSB-YP020834RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

大鼠Scn1a重組蛋白
貨號：

CSB-EP020834RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

大鼠Scn1a重組蛋白
貨號：

CSB-EP020834RA-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Scn1a重組蛋白
貨號：

CSB-BP020834RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Scn1a重組蛋白
貨號：

CSB-MP020834RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Scn1a
Uniprot No.：

P04774
別名：

Scn1a; Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.
基因功能參考文獻：
1. Nav1.1 in facilitates fast-firing properties in medial septum neurons. Nav1.1 deficits may disrupt information processing in Dravet syndrome via a dysregulation of theta wave brain rhythms. PMID: 26978272
2. Scn1a mutant rats demonstrate a higher hyperthermia-induced seizure susceptibility than wild type rats. PMID: 23375560
3. Hyperthermia-induced seizures occurred in Scn1a mutant rats at high-frequency electroencephalographic oscillations. PMID: 22920678
4. We show that reduction of Nav1.1 expression in the medial septum and diagonal band of Broca leads to a dysregulation of hippocampal oscillations in association with a spatial memory deficit PMID: 23318929
5. In the dorsal horn of the developing rat, Na(v) isoforms are developmentally regulated at the mRNA level in a subtype-specific manner, as Na(v)1.2 and Na(v)1.3 decreased significantly from P3 to adulthood, while Na(v)1.1 was upregulated during this period PMID: 23219908
6. Identification of the cysteine residue responsible for disulfide linkage of Na+ channel alpha and beta2 subunits PMID: 22992729
7. Results suggest that an early increase in dorsal root ganglion Nav1.1 expression after peripheral nerve injury might be involved in the induction of neuropathic pain. PMID: 21714116
8. Hyperthermia-induced seizure-susceptible rats are associated with febrile seizures and display the hyperexcitability of limbic neurons associated with the Scn1a missense mutation. PMID: 20875856
9. An important mechanism of electroacupuncture therapy is its regulation of Nav1.6 and Nav1.1 expression after ischemia. PMID: 20483028
10. Scn1a missense mutation preferentially impairs GABA(A) receptor-mediated synaptic transmission without directly altering the excitability of the pyramidal neurons in the hippocampus, which may be linked to the pathogenesis of febrile seizures. PMID: 20707984
11. TTX-sensitive sodium channel alpha-subunit isoforms Na(v)1.1, Na(v)1.2, Na(v)1.3, Na(v)1.4 and Na(v)1.6 were detected in neonatal rat heart but at levels reduced compared to the predominant cardiac alpha-subunit isoform, Na(v)1.5. PMID: 19426735
12. Quantitative and relative changes in expression of NaCh genes in neurons following injury produced by selective activation of voltage-gated sodium channels. Gene Nav1.1. may play role in neuronal injury/recovery process. PMID: 12835125
13. A novel site of high-density sodium channel clustering in the inner plexiform layer of the retina is described, marked by ankyrin-G and neurofascin. PMID: 15797713
14. these data map the time-dependent loss of Na(v)1.1 mRNA and protein following focal ischemic brain injury PMID: 15878599
15. Na(V)1.1 was distributed in a similar manner to Na(V)1.5: atrial & ventricular myocardium & the left bundle branch, the inferior nodal extension & transitional zone. PMID: 16966585
16. Results suggest that transient cerebral ischemia renders CA1 interneurons less excitable, that depressed excitability involves impaired Na(+) channel activation and that Na(+) channel dysfunction is explained by reduced expression of the Na(v)1.1 subunit. PMID: 17228331
17. This study combined ISH with immunohistochemistry and discovered that most of the PV-immunoreactive cells located at the INL/IPL border express Nav1.1. Our results show that AII amacrine cells express Nav1.1. PMID: 17709186
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Sodium channel (TC 1.A.1.10) family, Nav1.1/SCN1A subfamily
數(shù)據(jù)庫鏈接：

KEGG: rno:81574

STRING: 10116.ENSRNOP00000008026

UniGene: Rn.32079