Recombinant Rat Sodium- and chloride-dependent creatine transporter 1 (Slc6a8), partial

中文名稱：

大鼠Slc6a8重組蛋白
貨號：

CSB-YP021707RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Slc6a8重組蛋白
貨號：

CSB-EP021707RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Slc6a8重組蛋白
貨號：

CSB-EP021707RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Slc6a8重組蛋白
貨號：

CSB-BP021707RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Slc6a8重組蛋白
貨號：

CSB-MP021707RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Slc6a8
Uniprot No.：

P28570
別名：

Slc6a8Sodium- and chloride-dependent creatine transporter 1; CHOT1; CT1; Creatine transporter 1; Solute carrier family 6 member 8
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.
基因功能參考文獻：
1. CXCL12 contributes to cholinergic gene expression via Akt signaling pathway. PMID: 27941337
2. TP is expressed at high levels in human GBM tumors and shRNA knockdown of TP in U87 GBM cells results in a significant increase in cellular GCL enzymatic activity PMID: 23824558
3. The expression of CRT in cochlear tissues during development may reflect differential requirements for creatine-phosphocreatine buffering to replenish ATP consumed during energy-dependent metabolic processes. PMID: 22307408
4. Creatine/creatine kinase circuit may play an important role in sustaining or exacerbating acute seizure activity, but not chronic epileptic discharge. PMID: 20979657
5. plasma-membrane CRT is glycosylated and has an apparent monomer molecular mass of 58 kDa; furthermore, N-linked glycosylation is neither exclusively important for the function of CRT nor for surface trafficking, but affects both processes [CRT] PMID: 16167890
6. The maturation-dependant alterations of CK and LDH isoenzyme activities and of mitochondrial oxidative capacity were paralleled by a progressive increase of creatine transporter (CrT) expression, creatine uptake kinetics and creatine content in the heart. PMID: 20569423
7. AMPK inhibits apical membrane CRT/Slc6a8 expression in kidney proximal tubule cells, which could be important in reducing cellular energy expenditure and unnecessary creatine reabsorption under conditions of local and whole body metabolic stress. PMID: 20462973
8. Current results constitute the first description of the presence of a functional CRT in the axon terminal membrane that may serve to recapture the creatine released during the synapsis. PMID: 19804817
9. Data show that choline transporter-1 is restricted to motoneurons and absent from the non-neuronal ACh-synthesizing elements, and is enriched at neuro-neuronal and neuro-muscular synapses. PMID: 11904763
10. Noncompetitive binding of alcohol to choline carriers from immature male tissue. PMID: 12675122
11. CHT1 constitutively shuttles between plasma membrane and early endosomes; a CHT1 carboxyl-terminal tail dileucine-like motif mediates constitutive CHT1 endocytosis. PMID: 15953352
12. Activity and subcellular trafficking of the sodium-coupled choline transporter CHT is regulated acutely by peroxynitrite. PMID: 17971421
13. An influence of total Creatine on the brain's energy regulating system seems plausible. PMID: 18555535
14. creatine transporter in the rat brain is mainly confined to neurones located principally in regions involved in motor and sensory processing and in learning, memory and limbic functions PMID: 19580854
15. guanidinoacetate was transported from the circulating blood across the blood brain barrier most likely via a creatine transporter (CRT) PMID: 19682207
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A8 subfamily
組織特異性：

Expressed in brain, cerebellum, spinal cord, to a lesser extent, heart, but only very low expression in lung, kidney, and muscle.
數據庫鏈接：

KEGG: rno:50690

STRING: 10116.ENSRNOP00000025702

UniGene: Rn.10336