Recombinant Rat Serine/threonine-protein kinase DCLK1 (Dclk1)

中文名稱：

Recombinant Rat Serine/threonine-protein kinase DCLK1(Dclk1)
貨號：

CSB-YP006548RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rat Serine/threonine-protein kinase DCLK1(Dclk1)
貨號：

CSB-EP006548RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rat Serine/threonine-protein kinase DCLK1(Dclk1)
貨號：

CSB-EP006548RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rat Serine/threonine-protein kinase DCLK1(Dclk1)
貨號：

CSB-BP006548RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rat Serine/threonine-protein kinase DCLK1(Dclk1)
貨號：

CSB-MP006548RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Dclk1
Uniprot No.：

O08875
別名：

Dclk1; Cpg16; Dcamkl1Serine/threonine-protein kinase DCLK1; EC 2.7.11.1; Calcium/calmodulin-dependent protein kinase type I-like CPG16; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-433
氨基酸序列

MLELIEVNGT PGSQLSTPRS GKSPSPSPTS PGSLRKQRIS QHGGSSTSLS STKVCSSMDE NDGPGEEESD EGFQIPATIT ERYKVGRTIG DGNFAVVKEC IERSTAREYA LKIIKKSKCR GKEHMIQNEV SILRRVKHPN IVLLIEEMDV PTELYLVMEL VKGGDLFDAI TSTSKYTERD ASGMLYNLAS AIKYLHSLNI VHRDIKPENL LVYEHQDGSK SLKLGDFGLA TIVDGPLYTV CGTPTYVAPE IIAETGYGLK VDIWAAGVIT YILLCGFPPF RGSGDDQEVL FDQILMGQVD FPSPYWDNVS DSAKELINMM LLVNVDQRFS AVQVLEHPWV NDDGLPENEH QLSVAGKIKK HFNTGPKPSS TAAGVSVIAT TALDKERQVF RRRRNQDVRG RYKAQPAPPE LNSESEDYSP SSSETVRSPN SPF
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
基因功能參考文獻：
1. Electrical stimulated-neurite outgrowth is regulated by MicroRNA-363-5p through targeting of DCLK1. PMID: 27900578
2. The authors found that microtubule-binding protein doublecortin-like kinase 1 (DCLK1) labels a subset of dendritic microtubules and is required for KIF1-dependent dense-core vesicles (DCVs) trafficking into dendrites and dendrite development. PMID: 26758546
3. Results do not support DCAMKL-1 as a putative neoplastic stem cell marker in colonic tumors co-expressing nuclear beta-catenin. PMID: 23374535
4. DCX+DCLK depletion alters the behavior of growth cones at substrate borders. PMID: 23001563
5. Metrnl, Dclk1 and Serpinb1a have been identified as genes that are induced during the latent process (LP) for cell differentiation with distinct temporal expression profiles and are required for subsequent neurite extension. PMID: 22344266
6. DCLK isoforms are present in the paraventricular hypothalamic nucleus and Edinger-Westphal nucleus of mammalian brain, where they mediate neuronal plasticity in stress-sensitive brain centers. PMID: 20418180
7. The substrate specificity requirements of double cortin kinase-1 have been assessed, two potential regulatory domains have been identified, and evidence found for a possible activation loop-based mechanism. PMID: 12590608
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蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
數據庫鏈接：

KEGG: rno:83825

STRING: 10116.ENSRNOP00000019748

UniGene: Rn.155540