Recombinant Rat Serine protease inhibitor A3K (Serpina3k)

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中文名稱：

大鼠Serpina3k重組蛋白
品名簡稱：

Recombinant Rat Serpina3k protein
貨號：

CSB-EP361549RA
說明書：

MSDS Datasheet
規格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

Serpina3k
Uniprot No.：

P05545
別名：

Serpina3k; Spin2b; Serine protease inhibitor A3K; Serpin A3K; CPI-21; Contrapsin-like protease inhibitor 1; GHR-P63; Growth hormone-regulated proteinase inhibitor; Kallikrein-binding protein; KBP; SPI-2.3; Serine protease inhibitor 2; SPI-2; Thyroid hormone-regulated protein
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

52.0 kDa
表達區域：

21-416aa
氨基酸序列

DGILGRDTLPHEDQGKGRQLHSLTLASINTDFTLSLYKKLALRNPDKNVVFSPLSISAALAILSLGAKDSTMEEILEVLKFNLTEITEEEIHQGFGHLLQRLSQPEDQAEINTGSALFIDKEQPILSEFQEKTRALYQAEAFVADFKQCNEAKKFINDYVSNQTQGKIAELFSELDERTSMVLVNYLLFKGKWKVPFNPNDTFESEFYLDEKRSVKVPMMKIKDLTTPYIRDEELSCSVLELKYTGNASALFILPDQGKMQQVESSLQPETLKKWKDSLRPRIISELRMPKFSISTDYNLEEVLPELGIRKIFSQQADLSRITGTKNLHVSQVVHKAVLDVDETGTEGAAATAVTAALKSLPQTIPLLNFNRPFMLVITDNNGQSVFFMGKVTNPM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged and C-terminal Myc-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase.
基因功能參考文獻：
1. KBP suppressed lipopolysaccharide-induced TNF-alpha production via upregulating SOCS3 expression. PMID: 23129128
2. KBP competed with (125)I-VEGF for binding to endothelial cells and down-regulated VEGF production in endothelial cells and in the retina of the oxygen-induced retinopathy rat model PMID: 12743698
3. in a rat model of chronic mycardial infarction (MI) kallistatin improves cardiac performance and prevents post-MI-induced cardiac hypertrophy and fibrosis through its antioxidant action. PMID: 18762777
4. An inverse relationship exists between oxidative stress and kallistatin levels in the circulation and blood vessels. Kallistatin expression is negatively regulated by oxidative stress via JNK-dependent FOXO1 activation in cultured endothelial cells. PMID: 20081110
5. Pivotal role for alpha1-antichymotrypsin in skin repair PMID: 21693707
6. SERPINA3K is an antifibrogenic factor, and its antifibrogenic activity is through blocking the Wnt pathway. Decreased SERPINA3K levels may contribute to the fibrosis in diabetic retinopathy. PMID: 20299474
7. SERPINA3K is a high-affinity, endogenous antagonist of LRP6 PMID: 20351274
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亞細胞定位：

Secreted.
蛋白家族：

Serpin family
組織特異性：

Liver and plasma.
數據庫鏈接：

KEGG: rno:24794

STRING: 10116.ENSRNOP00000013896

UniGene: Rn.91257