Recombinant Rat Protein kinase C-binding protein NELL1 (Nell1)

中文名稱：

大鼠Nell1重組蛋白
貨號：

CSB-YP717291RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Nell1重組蛋白
貨號：

CSB-EP717291RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Nell1重組蛋白
貨號：

CSB-BP717291RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Nell1重組蛋白
貨號：

CSB-MP717291RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Nell1
Uniprot No.：

Q62919
別名：

Nell1; Protein kinase C-binding protein NELL1; NEL-like protein 1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

22-810
氨基酸序列

FGMDPDLQL DIISELDLVN TTLGVTQVAG LHNASKAFLF QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS GVILSIRELE HSYFELESSG PREEIRYHYI HGGKPRTEAL PYRMADGQWH KVALSVSASH LLLHIDCNRI YERVIDPPET NLPPGSNLWL GQRNQKHGFF KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI MDLQELLAKM TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCGNCTCKSG AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT KTCRECRGGV LVKITEACPP LNCSAKDHIL PENQCCRVCP GHNFCAEAPK CGENSECKNW NTKATCECKN GYISVQGNSA YCEDIDECAA KMHYCHANTV CVNLPGLYRC DCVPGYIRVD DFSCTEHDDC GSGQHNCDKN AICTNTVQGH SCTCQPGYVG NGTICKAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI DECAEGFVEC HNYSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR EDRCSVCSCK DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ KLYRSGDNWT HSCQQCRCLE GEADCWPLAC PSLGCEYTAM FEGECCPRCV SDPCLAGNIA YDIRKTCLDS FGVSRLSGAV WTMAGSPCTT CKCKNGRVCC SVDLECIENN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.
基因功能參考文獻：
1. NELL-1570 has the potential to be used for cell-based or hormone-based therapy of bone regeneration. PMID: 25376942
2. Thus, NELL-1 effectively enhances in situ osteogenesis in the bone marrow, making it potentially useful in the prevention and treatment of osteoporotic fractures. PMID: 23083222
3. Nell-1 can significantly improve bone regeneration in a femoral segmental defect in a dose-dependent manner and is a potent osteospecific growth factor. PMID: 21285762
4. Data show that Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure PMID: 12235118
5. Nell-1 overexpression disrupts these pathways resulting in craniofacial anomalies such as premature suture closure. PMID: 14672347
6. Nell1 accelerates chondrocyte hypertrophy and endochondral bone formation. PMID: 16243593
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亞細胞定位：

Cytoplasm. Nucleus envelope. Secreted.
數據庫鏈接：

KEGG: rno:81733

STRING: 10116.ENSRNOP00000052883

UniGene: Rn.10695